Cranberry for Prevention of Urinary Tract Infections in Multiple Scler
Prospective, Randomized, Double-blind, Placebo-controlled Study on Parallel Groups Evaluating the Efficacy and Safety of Cranberry (Vaccinium Macrocarpon) in Prevention of Urinary Tract Infections in Multiple Sclerosis Patients.
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Cranberry
Placebo
- Placebo
What it measured
Main measures
Time to onset of a first UTI within one year of treatment.
one year
Other measures (9)
Rate of patients with at least one UTI during the one-year treatment
Determined at M3, M6, M9 and M12
Number of UTI
Determined at M3, M6, M9 and M12
Score on Qualiveen® scale
Determined at M3, M6, M9 and M12
Symptomatology of urinary disorders
Determined at M3, M6, M9 and M12
Bladder, bowel and sexual functionEDSS score
Determined at M3, M6, M9 and M12
Disability progressionNumber of multiple sclerosis attacks
Determined at M3, M6, M9 and M12
RelapsesAntibiotics consumption
Determined at M3, M6, M9 and M12
Safety of cranberry
Determined at M3, M6, M9 and M12
SafetyPatients' observance to treatment
Determined at M3, M6, M9 and M12
Who could take part
MS (type not specified) · 18 to 70
Show the full criteria
Inclusion criteria
* Adults aged 18 to 70, with multiple sclerosis, neurologically stable for at least 3 months * With an EDSS score ≥ 3 * Symptomatic bladder dysfunction: frequency, urgency, dysuria, incontinence (at least one of these symptoms), needing intermittent catheterization or not * Ambulatory at inclusion * Able to undergo evaluation * Informed written consent Non-inclusion Criteria: * Regular consumption of cranberry within 3 months before inclusion * Symptomatic urinary tract infection at inclusion * Chronic renal failure (creatinin clearance \< 10ml/min) * Patients with urinary permanent catheterization * Patients with hyperuricemia and risk of uric acid lithiasis * Patients with oral anticoagulant treatment (antivitamins K) * Peptic ulcer * Intolerance to cranberry and/or excipients * Urinary tract infections antibioprophylaxis
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Bladder dysfunction occurs at some time in most patients with multiple sclerosis and these patients are prone to have recurrent urinary tract infections. Cranberry has been traditionally used for the treatment and prophylaxis of urinary tract infections but there is no reliable randomized controlled trial demonstrating evidence of cranberry's utility in this disease. The aim of our study is to assess the efficacy and safety of cranberry in the prophylaxis of urinary tract infections in patients with multiple sclerosis with a prospective randomized, double-blind and placebo-controlled clinical trial.
Papers
Results
Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial.Mult Scler · 2014
Results
Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Nov 10;11(11):CD001321. doi: 10.1002/14651858.CD001321.pub7.Results
Williams G, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023 Apr 17;4(4):CD001321. doi: 10.1002/14651858.CD001321.pub6.
Loading reviews and guidelines…
History
Started
Jan 2006
Main results due
Mar 2008
Finished
Oct 2008