Multiple Sclerosis and Heavy Progressive Resistance Training
Multiple Sclerosis and Muscle Function - Effects of Heavy Progressive Resistance Training
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Resistance training
What it measured
Main measures
Muscle strength (isokinetic testing)
Before and after the intervention
Physical function
Other measures (8)
Functional capacity (Six minute walk test, 10m walk test, chair rise, stair climbing)
Before and after the intervention
Walking and mobilityMuscle biopsies from m. vastus lateralis
Before and after the intervention
% Fat (skinfold)
Before and after the intervention
Blood samples (immunologic parameters)
Before and after the intervention
Fatigue (Fatigue Severity Scale - FSS, Modified Fatigue Inventory - MFI-20)
Before and after the intervention
FatigueHRQOL: SF36
Before and after the intervention
Quality of life (reported by participants)Depression: Major Depression Inventory (MDI)
Before and after the intervention
Mood and sleepSurface EMG from m. vastus lateralis during MVC
Before and after the intervention
Who could take part
Relapsing MS · 18 and over
Show the full criteria
Inclusion criteria
* Clinical diagnosis of Relapsing Remitting Multiple Sclerosis according to the McDonald criteria * Expanded Disability Status Scale Score between 3,0-5,5 * Be able to walk at least 100m * Be able to train twice a week at the University
Exclusion criteria
* Alcohol abuse, Alzheimer's and pacemaker * Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases * Having had an attack in a period of 8 weeks prior to the start of the intervention period * Having an attack during the intervention period * Pregnancy * Systematic resistance training in a period of 3 months prior to the start of the intervention period. * Training adherence of less than 85%.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of the present investigation is to determine whether MS patients can tolerate and benefit from heavy progressive resistance training. A second purpose is to determine both neural and muscle morphological adaptations to heavy progressive resistance training.
Papers
Results
Neural drive increases following resistance training in patients with multiple sclerosis.J Neurol · 2013
Results
Dalgas U, Severinsen K, Overgaard K. Relations between 6 minute walking distance and 10 meter walking speed in patients with multiple sclerosis and stroke. Arch Phys Med Rehabil. 2012 Jul;93(7):1167-72. doi: 10.1016/j.apmr.2012.02.026. Epub 2012 Mar 12.
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History
Started
Nov 2006
Main results due
Mar 2008
Finished
Jun 2008