Management of Pain in Persons With Multiple Sclerosis

Pilot Study of CBT and Self-hypnosis Training for Pain in Persons With Multiple Sclerosis

CompletedNot a drug-phase studyMS (type not specified)NCT00621374

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Cognitive Behavioral Therapy (CBT) +Hypnosis (HYP)
  • Cognitive Behavioral Therapy (CBT)
  • Self-Hypnosis Training (HYP)
  • Education Control (CONT)

What it measured

Main measures

  • A composite of average daily pain intensity measured using a 0-10 NRS via four phone interviews performed on different days by research staff.

    Before treatment, after each treatment module, and 1-month after the final treatment module.

    Pain

Other measures (9)

  • Sleep quality- Medical Outcomes Sleep Study Measure (Hays et al., 2005)

    before treatment, after each treatment module, one month after 4th treatment modules

    Mood and sleep

  • Depression- (CMDI; Nyenhuis et al., 1998)

    before treatment, after each treatment module, one month after 4th treatment modules

    Mood and sleep

  • Catastrophizing cognitions- (PCS; Sullivan et al. 1995)

    before treatment, after each treatment module, one month after 4th treatment modules

    Thinking and memory

  • Adaptive cognitions (CPAQ; McCracken et al., 2004)

    before treatment, after each treatment module, one month after 4th treatment modules

    Thinking and memory

  • Distinguishing neuropathic vs. non-neuropathic pain (S-LANSS; Bennett et al., 2005)

    before treatment, after each treatment module, one month after 4th treatment modules

    Pain

  • Pain Interference-(Brief Pain Inventory, Cleeland et al., 1994)

    before treatment, after each treatment module, one month after 4th treatment modules

    Pain

  • Impact of Fatigue (FIS; Fisk et al. 1993)

    before treatment, after each treatment module, one month after 4th treatment modules

    Fatigue

  • Fatigue Severity (FSS; Krupp et al., 1989)

    before treatment, after each treatment module, one month after 4th treatment modules

    Fatigue

  • Health Status (SF-36; Ware et al., 1992)

    before treatment, after each treatment module, one month after 4th treatment modules

    Quality of life (reported by participants)

Who could take part

MS (type not specified) · 18 and over

Show the full criteria

Inclusion criteria

* Chronic ongoing pain (i.e., pain at all times) with an average pain intensity of at least 4/10 on 0-10 numeric rating scale * Pain is either worse or started since the onset of other MS symptoms. * Pain of at least six months duration. * Reads, speaks and understands English. * Definitive diagnosis of multiple sclerosis (MS) * At least 18 years of age * Recruited from a recruitment source approved by the IRB

Exclusion criteria

* Severe cognitive impairment resulting in the inability to verbally comprehend, learn, and recall new auditory verbal information, as reflected by a TICS score of 20 or less. * Currently participating in counseling and/or psychotherapy more than once a week. * Currently taking anti-psychotic medications * Has been hospitalized for psychiatric reasons in the past six months * Experiencing current active suicidal ideation. * Has received treatment or participated in a clinical trial that involved significant elements of either CBT or hypnosis within the past year.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The purpose of this study is to see if treatments that include components of self-hypnosis training and cognitive behavioral therapy (CBT) can help decrease pain in people with MS.

Papers

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History

    1. Started

      Feb 2008

    2. Main results due

      Jun 2009

    3. Finished

      Jun 2009

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