Characterization of Interferon Beta -1b-Induced Tolerizing Effect in D
Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells
What it found
We found no results in the registry or in papers.
This trial finished 16 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- IFNbeta-1b
What it measured
Main measures
Determine the effect of IFN-B-1b-induced SOCS3 upregulation in DCs' on their maturation and the capacity to present
2 years
Other measures (1)
Characterize the effect of IFN-1b-induced SOCS3 expression in DCs on Th1/Th2 cell differentiation and T-cell cytokine transcription.
2 years
Immune response
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
* Confirmed diagnosis of MS * Age 18-60 years, inclusive * Expanded disability status of 0-6.5 * Give written informed consent prior to any testing under this protocol
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Determine the in-vivo mechanism of action of INF-B-1b as it's mechanisms of action are not completely understood. We propose that high dose exogenous recombinant IFN-B-1b induces tolerizing effect on DC-dependent T-cell differentiation in patients with MS by inducing the expression of SOCS3 in DCs.
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History
Started
Sept 2007
Main results due
May 2010
Finished
Mar 2011