Longitudinal (Weekly) Follow-up of Active Plaques in Multiple Sclerosi
Longitudinal (Weekly) Follow-up of Active Plaques in Multiple Sclerosis With 3 Teslas Multi-modality MRI Using Diffusion, Perfusion, Venography and Proton Spectroscopy
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- 3T MR scanner
What it measured
Main measures
Modification of MR parameters before and after the blood brain barrier disruption observed in newly enhancing lesion in MS.
each week for 2 months, at 6 month and at 12 month
MRI lesions
Other measures (2)
Predictive scorers of plaque transformation in "black-holes", which correspond with a pejorative evolution of accurate lesions, also defined by a focal destruction of cerebral tissue.
each week for 2 months, at 6 month and at 12 month
MRI lesionsRelation between plaques development and cerebral venous structures.
each week for 2 months, at 6 month and at 12 month
Who could take part
MS (type not specified) · 18 to 50
Show the full criteria
Inclusion criteria
* Age between 18 and 50 years. * Health coverage. * Any form of MS defined by Mc Donald's criteria (2005). * Patients having shown an enhanced plaque on a less than six month MRI examination.
Exclusion criteria
* Patients with an immunomodulating therapy like natalizumab (Tysabri) and intravenous immunosuppressive therapies. Other therapies will not be excluded from this study. For patients treated by systemic corticotherapy, a one-month delay will be necessary before a MRI examination. * Cerebral microangiopathy (diabetes, arterial hypertension, vascularitis…) * Patient with classical MRI contraindication like pace-maker, cardiac valvulosis, claustrophobia, allergy to contrast agent … * Pregnancy or pregnancy desire. * Patient with a low creatinine clearance \<60 ml/mn
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
It is difficult to determinate prognostic criteria of Multiple Sclerosis with conventional MRI insofar as physiopathology is not well-known: the precise sequences of events leading to plaque formation and axonal injury are still not completely understood. Some elements involved in plaque formation can be studied thanks to MR techniques (cerebrospinal fluid and periveinular spaces, neuronal injury, microglia, and cerebral microcirculation's dysfunction). This study aims at giving a better understanding of MS plaques' physiopathology, using data from modern MRI through a longitudinal followed up with weakly MR 3T examination.
Papers
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History
Started
Feb 2009
Main results due
Jul 2012
Finished
Jul 2012