Motor Training and White Matter in Multiple Sclerosis (MS)
The Influence of a tDCS Combined Long-term Motor Training Program on Structural White Matter Changes in the Brain, Functionality and Psychological Outcome Measures in Multiple Sclerosis.
What it found
The trial ended early for another reason (see below).
This trial finished 14 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- tDCS
- Bimanual Training
What it measured
Main measures
Change in White Matter
Baseline, immediately after and 3 weeks after the intervention
MRI lesionsMyelin repair
Other measures (2)
Change in Quality of Life
Baseline, immediately after and 3 weeks after the intervention
Quality of life (reported by participants)Blood sample
After the end of the study
Who could take part
MS (type not specified) · 18 to 68 · EDSS 2 to 6.5
Show the full criteria
Inclusion criteria
* Expanded Disability Status Scale (EDSS) scores between 2 and 6.5 * Stable MS (no relapse during the last 3 months before study onset) * age: between 18 and 68 years
Exclusion criteria
* Patients with other pathologies associated with peripheral and/or central sensory dysfunction or under psychotropic or antiepileptic medication. * Standard TMS/tDCS and MRI exclusion criteria (safety questionnaires)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In the current study the researchers will firstly investigate whether a bimanual coordination training protocol (20 min/day, for 8 consecutive weeks) correlates with changes in white matter architecture and improved upper-limb functionality in patients with multiple sclerosis. Secondly, the researchers predict that motor learning is more efficient when it is combined with anodal transcranial direct current (tDCS) stimulation on the left primary motor cortex.
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History
Started
Jan 2011
Main results due
Dec 2011
Finished
May 2013