Melatonin in Relapsing-Remitting Multiple Sclerosis Patients
Effects of Melatonin on Clinical and Neuroimaging Indices of Relapsing-Remitting Multiple Sclerosis Patients
What it found
We found no results in the registry or in papers.
This trial finished 12 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Melatonin
Melatonin receptor agonist
What it measured
Main measures
Number of relapses
one year
RelapsesEDSS
one year (every 3 months)
Disability progressionPASAT-3 score
one year (at the beginning and end of the year)
Thinking and memoryproportion of brain gray matter volume to intracranial volume
one year (at the beginning and end of the year)
Brain volume loss
Other measures (1)
MSFC score
one year (at the beginning and end of the year)
Disability progressionThinking and memory
Who could take part
Relapsing MS · 20 to 45
Show the full criteria
Inclusion criteria
* definite diagnosis of relapsing-remitting multiple sclerosis * EDSS \<=5 * at least 6months consumption of interferon beta 1a
Exclusion criteria
* illiteracy * evidence of Nystagmus or visual acuity lower than 5/10 in each of the eyes * relapse in the last 3 months * pregnancy or deciding to become pregnant during the following year * regulatory consumption of warfarin, nifedipine, nonsteroidal anti-inflammatory drugs (NSAIDs), beta-blockers, fluvoxamine, isoniazide, progestin * history of epilepsy, stroke, major depression, endocrine, hepatic, hematologic, and nephrologic diseases
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study is to determine whether melatonin is effective in the treatment of relapsing-remitting multiple sclerosis patients as a supplement to the main disease-modifying drugs.
Papers
Loading reviews and guidelines…
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History
Started
Oct 2010
Main results due
Jan 2014
Finished
Feb 2014