Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient
The Impact of Vitamin A Supplementation on Gene Expression of Cytokine Secreted by CD4+ T Lymphocyte in Multiple Sclerosis Patients
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Retinol
What it measured
Main measures
serum Total cholesterol
Change from baseline at 6 months
serum HDL cholesterol
Change from baseline at 6 months
serum triglycerides level
Change from baseline at 6 months
RBP/ TTR ratio
Change from baseline at 6 months
PBMC's prolifration(BrdU colorimetric)
Change from baseline at 6 months
complete blood count (CBC)
Change from baseline at 6 months
serum SGOT concentration
Change from baseline at 6 months
serum SGPT concentration
Change from baseline at 6 months
Other measures (1)
gene expression of T-bet, INF-gamma, IL-4, GATA3, IL-17, RORc, IL-10, FOXP3 (Relative quantification)
Change from baseline at 6 months
Immune response
Who could take part
Relapsing MS · 20 to 45
Show the full criteria
Inclusion criteria
Patients who have used interferon beta in last 3 months. Patients with 1-5 EDSS
Exclusion criteria
* Patients who have diseases which affect on Th1/Th2 balance such as asthma, active viral infections, and autoimmune diseases, OR * Patients who have allergy to vitamin A compounds, OR * Patients who have used vitamin supplements in last 3 months. -
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The aim of this study is the comparison between the effects of supplementation with vitamin A (retinyl palmitate) or placebo for 6 months on gene expression of T CD4+ lymphocyte in multiple sclerotic patient.
Papers
Loading reviews and guidelines…
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History
Started
Apr 2011
Main results due
Apr 2013
Finished
Sept 2013