Impact of Vitamin A on Multiple Sclerosis (MS)
Impact of Vitamin A Supplementation on Disease Activity and Progression in Multiple Sclerotic (MS) Patients
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Retinol
Placebo
- Drug: placebo
What it measured
Main measures
Expanded Disability Status Scale (EDSS)
Change from baseline at 12 months
Disability progressionMultiple Sclerosis Functional Composite (MSFC)
Change from baseline at 12 months
Disability progressionfatigue scores
Change from baseline at 12 months
Fatiguedepression score
Change from baseline at 12 months
Mood and sleepNumber of active lesion in magnetic resonance imaging (MRI) number of active lesion in brain MRI
Change from baseline at 12 months
MRI lesions
Other measures (1)
number of disease relapses
Change from baseline at 12 months
Relapses
Who could take part
Relapsing MS · 20 to 45
Show the full criteria
Inclusion criteria
* Patients who have used interferon beta in last 3 months * Patients with 0-5 EDSS
Exclusion criteria
* Patients who have diseases which affect on Th1/Th2 balance such as asthma, active viral infections, and autoimmune diseases, OR * Patients who have allergy to vitamin A compounds, OR * Patients who have used vitamin supplements in last 3 months.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The aim of this study is the comparison between the effects of supplementation with 25000 IU preformed vitamin A (retinyl palmitate) or placebo for first 6 months and 10000 IU/day for next 6 months on disease activity and progression in patients with Multiple Sclerosis.
Papers
Results
Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial.Iran J Allergy Asthma Immunol · 2016
Results
Bitarafan S, Saboor-Yaraghi A, Sahraian MA, Nafissi S, Togha M, Beladi Moghadam N, Roostaei T, Siassi F, Eshraghian MR, Ghanaati H, Jafarirad S, Rafiei B, Harirchian MH. Impact of Vitamin A Supplementation on Disease Progression in Patients with Multiple Sclerosis. Arch Iran Med. 2015 Jul;18(7):435-40.
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History
Started
Feb 2010
Main results due
Feb 2013
Finished
Aug 2013