Metabolic Effects of a Green Tea Extract in Multiple Sclerosis Patient
Metabolic Effects of a Green Tea Extract in Multiple Sclerosis Patients
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Capsules with 160 mg Teavigo (at least 94% EGCG)
Placebo
- Placebo
What it measured
Main measures
Fasting and postprandial lipid oxidation in grams per hour, assessed by indirect calorimetry, after 3 months intake of green tea extract versus placebo
Three months
Who could take part
Relapsing MS · 20 to 60
Show the full criteria
Inclusion criteria
* Patients with relapsing-remitting multiple sclerosis * stable treatment with glatiramer acetate at least 6 months prior to inclusion * Expanded disability status scale \< 4.5 * Normal weight, overweight
Exclusion criteria
* Primary or secondary progressive forms of multiple sclerosis * Clinically relevant heart, lung, liver, kidney diseases * Habitual caffeine intake over 300 mg per day * Habitual consumption of green tea * Alcohol or drug abuse
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study aims to investigate metabolic effects of a standardized green tea extract, containing a defined amount of epigallocatechin-3-gallate (EGCG), in multiple sclerosis patients.
Papers
Results
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation.Acta Neuropathol · 2015
Results
Mahler A, Steiniger J, Bock M, Klug L, Parreidt N, Lorenz M, Zimmermann BF, Krannich A, Paul F, Boschmann M. Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial. Am J Clin Nutr. 2015 Mar;101(3):487-95. doi: 10.3945/ajcn.113.075309. Epub 2015 Jan 14.
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History
Started
Jul 2011
Main results due
Nov 2012
Finished
Jan 2013