Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis
The Investigation Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
What it found
The main measure did not show a significant benefit.
“Average thickness of RNFL at the end of trial did not differ between groups.”Read by software from the paper's abstract
changes in thickness of RNFL and macula 6 months after treatment · 6 months
| Group | n | Value |
|---|---|---|
| vitamin D | 27 | mean (SD) RNFL thickness decreased from 111.3 (18.9) μm at baseline to 91.4 (13.3) at end of study (P < 0.001) |
| placebo | 25 | mean (SD) RNFL thickness decreased from 113.7 (21.5) μm at baseline to 96.1 (12.3) at end of study (P < 0.01) |
p = > 0.05 for macula thickness change; RNFL between-group difference not significant
Total participants: 52
Read by software from the paper's abstract
What was tested
Treatment tested
- Ergocalciferol
Vitamin D receptor agonist
Placebo
- Vitamin D withheld
What it measured
Main measures
measurement Retinal nerve fiber layer (RNFL) thickness by OCT
10-32 days after optic neuritis
Retina scans (OCT)
Other measures (1)
measurement RNFL thickness by OCT
6 months after optic neuritis
Retina scans (OCT)
Who could take part
Optic neuritis · 15 to 50
Show the full criteria
Inclusion criteria
* age 15-50 years * no history of demyelinative events * level of vitamin d below 20 ng/ml * no pass 10-32 day from starting symptom
Exclusion criteria
* using vitamin D supplement
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study examines the effect of vitamin D on Retinal changes in patient with optic Neuritis.
Papers
Results
Salari M, Janghorbani M, Etemadifar M, Dehghani A, Razmjoo H, Naderian G. Effects of vitamin D on retinal nerve fiber layer in vitamin D deficient patients with optic neuritis: Preliminary findings of a randomized, placebo-controlled trial. J Res Med Sci. 2015 Apr;20(4):372-8.Average thickness of RNFL at the end of trial did not differ between groups.
Read by software from the paper's abstract
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History
Started
Jul 2011
Main results due
Jul 2012
Finished
Dec 2012