Occupational Therapy in Patients With Multiple Sclerosis
Apraxia-specific Occupational Therapy in Patients With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Occupational Therapy
- Physical therapy
What it measured
Main measures
Change in apraxia score as measured by TULIA
From day of randomisation to end of study, expected to be after 4 weeks
Other measures (4)
Change in manual dexterity
From day of randomisation to end of study, expected to be after 4 weeks
Arm and hand functionChange in activities of daily living
From day of randomisation to end of study, expected to be after 4 weeks
Change in quality of life
From day of randomisation to end of study, expected to be after 4 weeks
Quality of life (reported by participants)Change in fatigue
From day of randomisation to end of study, expected to be after 4 weeks
Fatigue
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
* Patients with all forms of MS * Age 18-60 years
Exclusion criteria
* Any disease other than multiple sclerosis that could possibly explain the patient's signs and symptoms * A relapse which started within 60 days prior to the examination * Uncontrolled, clinically significant heart diseases, such as arrhythmias, angina, Coronary heart disease or uncompensated congestive heart failure, medication with glycosides. * A history of drug abuse in the 6 months prior to screening
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Limb apraxia is defined as the inability to correctly perform skilled and/or learned limb movements, which cannot be explained by elementary motor and sensory deficits or cognitive problems. Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system and the leading cause of disability in young adults. Apraxia and impaired manual dexterity are common problems in patients with MS leading to impaired activities of daily living. However, a specific training program to improve apraxia as well as manual dexterity in MS is lacking. In this study, the investigators want to evaluate the impact of a targeted occupational therapy program on apraxia and manual dexterity in patients with MS that have dexterity problems. Patients routinely seen in the investigators MS consulting hour, fulfilling all inclusion and exclusion criteria and willing to participate in the study will be evaluated for Apraxia and manual dexterity. In case of Apraxia and/or impaired manual dexterity, patients will be randomized 1:1 using sealed envelopes to receive occupational home therapy (experimental group) or general physical exercises (control group) for 4 weeks. At study entry and study end after 4 weeks, apraxia and manual dexterity will be tested in all patients.
Papers
Results
Home-based training to improve manual dexterity in patients with multiple sclerosis: A randomized controlled trial.Mult Scler · 2015
Background
Vanbellingen T, Kersten B, Van de Winckel A, Bellion M, Baronti F, Muri R, Bohlhalter S. A new bedside test of gestures in stroke: the apraxia screen of TULIA (AST). J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):389-92. doi: 10.1136/jnnp.2010.213371. Epub 2010 Oct 9.Background
Bohlhalter S, Vanbellingen T, Bertschi M, Wurtz P, Cazzoli D, Nyffeler T, Hess CW, Muri R. Interference with gesture production by theta burst stimulation over left inferior frontal cortex. Clin Neurophysiol. 2011 Jun;122(6):1197-202. doi: 10.1016/j.clinph.2010.11.008. Epub 2010 Dec 3.
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History
Started
Jan 2012
Main results due
Dec 2012
Finished
Dec 2012