Multiple Sclerosis and Progressive Resistance Training

Multiple Sclerosis - Inflammatory, Neurological and Muscular Adaptations to Progressive Resistance Training

CompletedNot a drug-phase studyRelapsing MSNCT01518660

What it found

No results found

We found no results in the registry or in papers.

This trial finished 12 years ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Training

What it measured

Main measures

  • Blood-borne biomarkers

    Change from baseline to 24 weeks

    Blood or spinal fluid markersImmune response

Other measures (6)

  • Neuro-muscular function of knee extensors

    Change from baseline to 24 weeks

    Physical function

  • Walking performance

    Change from baseline to 24 weeks

    Walking and mobility

  • Self-reported measures

    Change from baseline to 24 weeks

    FatigueWalking and mobilityMood and sleepQuality of life (reported by participants)

  • Brain volume

    Change from baseline to 24 weeks

    MRI lesionsBrain volume loss

  • Body Composition

    Change from baseline to 24 weeks

    Physical function

  • Thigh muscle cross-sectional area

    Change from baseline to 24 weeks

    MRI lesions

Who could take part

Relapsing MS · 18 to 60 · EDSS 2.0 to 5.5

Show the full criteria

Inclusion criteria

* Diagnosed relapsing-remitting MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) between 2.0 and 5.5 * Be able to train twice a week at the University * Use interferon based medication

Exclusion criteria

* Alcohol abuse, Alzheimer's and pacemaker (or other metallic implant) * Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases * Having had an attack in a period of 8 weeks prior to the start of the intervention period * Having an attack during the intervention period * Pregnancy * Systematic resistance training in a period of 3 months prior to the start of the intervention period. * Training adherence of less than 85%.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The purpose of this study is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.

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History

    1. Started

      Feb 2012

    2. Main results due

      Jan 2014

    3. Finished

      Jan 2014

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