Study of Lisdexamfetamine Sulfate to Treat Cognitive Dysfunction in Mu
Effects of Lisdexamfetamine on Bradyphrenia in Multiple Sclerosis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Lisdexamfetamine
Placebo
- placebo
Results by group
Symbol Digit Modalities Test (SDMT)
8 weeks
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Lisdexamfetamine Sulfate | 36.9 score on a scale | 8.7 (Standard Deviation) | 29 |
| Sugar Pill | 46.8 score on a scale | 7.5 (Standard Deviation) | 19 |
Lisdexamfetamine Sulfate
Sugar Pill
Paced Auditory Serial Audition Test (PASAT)
8 Weeks
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Lisdexamfetamine Sulfate | 32.0 score on a scale | 12.5 (Standard Deviation) | 29 |
| Sugar Pill | 37.4 score on a scale | 12.1 (Standard Deviation) | 19 |
Lisdexamfetamine Sulfate
Sugar Pill
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Lisdexamfetamine Sulfate | 41 | 0 (0.0%) | |
| Sugar Pill | 22 | 0 (0.0%) |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Symbol Digit Modalities Test (SDMT)
8 weeks
Thinking and memoryPaced Auditory Serial Audition Test (PASAT)
8 Weeks
Thinking and memory
Other measures (5)
California Verbal Learning Test - 2nd Edition
8 weeks
Thinking and memoryBrief Visuospatial Memory Test - Revised
8 weeks
Thinking and memoryVitals
8 weeks
Vitals (Diastolic Blood Pressure)
8 weeks
Vitals (Systolic Blood Pressure)
8 weeks
Who could take part
Relapsing and progressive · 18 to 55
Show the full criteria
Inclusion criteria
* Males/Females who are ≥ 18 years old and \< 55 years old and are capable of understanding and complying with the protocol, including speaking and writing fluent English and having at least a 9th grade education. * Have a diagnosis of either Relapsing Remitting or Secondary Progressive MS, as per revised McDonald's Criteria (68). * Have not received steroids in last thirty (30) days or a relapse in the last ninety (90) days, and whose MS is considered stable. * Presence of cognitive dysfunction characterized by slowed processing speed as indicated by a score of -1.5 SD below age/education matched norms on the SDMT or the PASAT. * An Expanded Disability Status Scale (EDSS) of ≤ 6.5 * Have given written informed consent prior to any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to his/her future medical care. * Are capable of performing the requirements of a NP test battery including at least 20/70 near visual acuity by near vision chart, with correction allowed. * If female, must neither be pregnant nor breast-feeding and must either (a) be > 12 months post-menopausal or surgically sterilized, or (b) agree to use an acceptable method of birth control for the duration of the study. Abstinence will not be considered an acceptable method of birth control.
Exclusion criteria
* Have cognitive deficits caused by concomitant medication usage or other significant neurological/psychological disease e.g. Alzheimer's disease, Parkinson's disease, stroke, transient ischemic attack, Vascular Dementia, Huntington's disease, traumatic brain injury or chronic CNS infection * Have evidence of other medical cause(s) of cognitive impairment * Have evidence of major depression as determined by a positive BDIFS and clinician interview * Have uncontrolled or labile hypertension, tachycardia, cardiovascular or cerebrovascular disease * Have demonstrated a hypersensitivity to amphetamines in the past * The following concomitant medications are not permitted to be used within 28 days of enrollment or during the study * Monoamine Oxidase Inhibitors * Inhaled Beta2-agonists * Sympathomimetics * Antipsychotic agents * Modafinil * Tricyclic Antidepressants * Anticonvulsants other than gabapentin and pregabalin * The following medications are permitted if the patient has been on a stable dose for ≥ 6 weeks: * Short acting benzodiazepines, qhs administration only * Gabapentin and pregabalin Cholinesterase inhibitors other than donepezil, galantamine, and rivastigmine * Memantine * Anti-spasmodics * Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Amphetamines have been shown to improve cognition but its use is limited due to its side effects. Lisdexamfetamine is an amphetamine pro-drug, minimizing these effects and has been safely used in children and adults with Attention Deficit Hyperactivity Disorder (ADHD). The investigators hypothesize that lisdexamfetamine may improve cognitive abilities in MS patients with documented cognitive dysfunction. Because lisdexamfetamine is a stimulant its positive effects should be observed primarily in the domains of processing speed and working memory. The investigators therefore propose a study in which the primary objective will be to assess the efficacy of lisdexamfetamine in improving attention and processing speed in MS. The secondary objectives will be (a) the assessment of the safety and tolerability of lisdexamfetamine in the MS population, and (b) to test for effects of the drug on other cognitive domains, depression, and self and informant reports of cognitive and executive function demanding activities and behaviors.
Papers
Loading reviews and guidelines…
History
Started
Nov 2009
Main results due
Aug 2011
Finished
Aug 2011
Results posted
Sept 2022