Evaluating Intervention Responsiveness in People With Multiple Scleros
Evaluating Intervention Responsiveness in People With Multiple Sclerosis
What it found
We found no results in the registry or in papers.
This trial finished 11 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- progressive resistance training
What it measured
Main measures
Change in maximal voluntary contraction of the hip flexors from baseline to end of training and to post-training
Participants are assessed at baseline (visit 1, enrollment), end of training (visit 2, week 12) and post-training (visit 3, week 24).
MRI lesionsPhysical function
Who could take part
MS (type not specified) · 21 to 75
Show the full criteria
Inclusion criteria
* Confirmed diagnosis of MS * If on immunomodulatory therapy, subjects have to have been on that therapy for at least 6 months prior to the start of the study. * Medically stable * Able to follow complex directions as determined by a score of less than or equal to 1 on a subset of questions taken from the NIH Stroke scale * Normal passive range of motion at the hips, knees, and ankles with minimum to no pain
Exclusion criteria
* Evidence of other neurological deficit that could interfere, such as previous stroke or muscle disease * Congestive heart failure * MS exacerbation within 8 weeks of study start * MS exacerbation affecting CST or DC-ML tracts * peripheral artery disease with claudication * cancer * pulmonary or renal failure * unstable angina * uncontrolled hypertension (greater than 190/110 mmHg) * orthopedic or pain conditions * history of kidney disease, due to potential of gadolinium reactions leading to nephrogenic systemic fibrosis (NSF) * because pregnancy may change the MRI signals that we are studying, we have chosen not to enroll pregnant women in this study Healthy controls have the same age and exclusion criteria as people with multiple sclerosis except that they must have normal neurological function
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose is to see how multiple sclerosis (MS) is associated with strength and sensation using MRI, in persons with MS. The investigators will also see whether exercise can improve these symptoms for persons with MS.
Papers
Loading reviews and guidelines…
History
Started
Apr 2012
Main results due
Sept 2015
Finished
Sept 2015