Effectiveness of Web-based Treatment for Depression in Patients With N
Evaluation of the Effectiveness of a Web-based Treatment Program for Depression (Deprexis) for the Reduction of Depressive Symptoms in Patients With Multiple Sclerosis and Epilepsy. A Randomized Controlled Trial
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Deprexis
Compared with
- Wait-list
What it measured
Main measures
Severity of depressive symptoms
7 Days
Mood and sleep
Other measures (1)
quality of life
14 days
Quality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* presence of a confirmed diagnosis of multiple sclerosis or epilepsy * self-reported urge to be treated for depressive symptoms (no externally confirmed diagnosis necessary) * informed consent (provided online in line with regulations by the Hamburg Department of Data Security)
Exclusion criteria
* unable to provide informed consent * diagnosis of bipolar or schizophrenia spectrum disorders * substantial neurocognitive impairment (e.g. dementia) * acute suicidal tendencies as assessed with the Suicide Behaviors Questionnaire-Revised (SBQ-R). Subjects excluded for this reason are provided various emergency contacts and phone numbers.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
200 persons (100 with multiple sclerosis and 100 with epilepsy) with depressive symptoms are recruited via the multiple sclerosis clinics of the University Medical Center Hamburg-Eppendorf and the epilepsy centre Alsterdorf and randomly assigned either to the online program deprexis or to a wait-list control condition. All participants receive free-of-charge online access to deprexis either immediately or with a six month delay. At three time points (1. prior to intervention, 2. after completion of the intervention nine weeks later and 3. at follow-up six month later), both groups are assessed via an anonymous online survey, which was implemented using the software package OPST®. The survey consists of different questionnaires. The Beck Depression Inventory (BDI) represents the primary outcome (IIT analysis for pre versus post). It is assumed that the severity of depressive symptoms will improve to a significantly greater extent in the deprexis than in the wait-list control condition in the course of nine weeks and will be maintained in a six month follow-up.
Papers
Results
An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial.Lancet Psychiatry · 2015
Results
Schroder J, Bruckner K, Fischer A, Lindenau M, Kother U, Vettorazzi E, Moritz S. Efficacy of a psychological online intervention for depression in people with epilepsy: a randomized controlled trial. Epilepsia. 2014 Dec;55(12):2069-76. doi: 10.1111/epi.12833. Epub 2014 Nov 19.Background
Moritz S, Schilling L, Hauschildt M, Schroder J, Treszl A. A randomized controlled trial of internet-based therapy in depression. Behav Res Ther. 2012 Aug;50(7-8):513-21. doi: 10.1016/j.brat.2012.04.006. Epub 2012 May 3.Background
Meyer B, Berger T, Caspar F, Beevers CG, Andersson G, Weiss M. Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial. J Med Internet Res. 2009 May 11;11(2):e15. doi: 10.2196/jmir.1151.
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History
Started
Jun 2012
Main results due
Dec 2013
Finished
Feb 2014