Effect of Melatonin on Multiple Sclerosis Related Fatigue
Study of Melatonin in Treatment of Fatigue in Multiple Sclerosis
What it found
We found no results in the registry or in papers.
This trial finished 14 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Melatonin
Melatonin receptor agonist
Placebo
- Placebo
What it measured
Main measures
Fatigue
at one month after treatment
Thinking and memoryFatigue
Other measures (1)
Quality Of Life
at one month after treatment
Quality of life (reported by participants)
Who could take part
Relapsing MS · 18 to 55
Show the full criteria
Inclusion criteria
1. definite diagnosis of relapsing-remitting MS (RRMS) by the MacDonald criteria 2. a baseline of Expanded Disability Status Score (EDSS)of less than 5.0 3. aged between 18 and 55 years of either sex 4. treated with one type of interferon beta-1a (IFNB-1a); 5. signed an informed consent
Exclusion criteria
1. clinical relapsing of MS during past 30 days; 2. use of melatonin and warfarin within 30 days prior to participation; 3. concomitant use of beta-blockers, anti-diabetic agents, antiplatelet agents, NSAIDS, aspirin ; 4. working more than one nighttime shift per month; 5. Pregnancy or lactation; 6. history of a chronic hematological, cardiac, hepatic, renal or thyroid disorders ; 7. failure to adhere to the study protocol
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study was to evaluate the efficacy and safety of Melatonin in treatment of fatigue and Quality of Life of MS patients.
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History
Started
May 2012
Main results due
Oct 2012
Finished
Oct 2012