Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity

Status unknownPhase 4MS (type not specified)NCT01786005

What it found

No results found

We found no results in the registry or in papers.

What was tested

Treatment tested

  • Transcranial magnetic stimulation

What it measured

Main measures

  • Stroke

    20 days

  • Epileptic seizure

    20 days

Other measures (1)

  • The patient is discharged from clinic

    20 days

Who could take part

MS (type not specified) · 18 to 70

Show the full criteria

Inclusion criteria

The age of the patients and healthy volunteers from 18 to 70 years * persons with confirmed and verified lesion of the central nervous system (the effects of CVD, multiple sclerosis, traumatic brain injury, SMC) with symptoms of spasticity any vyrazhenngosti; * informed consent; * healthy volunteers who gave informed consent to participate in the study. The criteria included: * The presence of an implanted pacemaker, intracardiac catheters, electronic pumps; * The difficult patient, requiring the maintenance of vital functions by hardware (mechanical ventilation, continuous application infusomats), including an increase of neurological symptoms after 8 days from the start of CVD, acute myocardial infarction, venous thrombosis of the lower extremities, episodes of pulmonary embolism; * The severity of the neurological deficit, which does not allow the patient to go through 10 meters (you can use an additional support); * Pregnancy or possibility of pregnancy in women of childbearing age (before menopause), according to a pregnancy test; * The presence of metal implants or in the head area, located closer than 20 cm from the edge of the surface coil magnetic stimulator, with the exception of the mouth (metal brackets, vascular sutures, metal plate covering defects in the skull, metallic foreign body in the cavity of the skull); * Identification of epileptiform activity during the screening EEG prior to the study; * Epilepsy or seizures in history; * Failure of a patient to participate in the study;

Exclusion criteria

* Identification of the study a total intolerance to a pulsed magnetic field; * Development after inclusion of acute myocardial infarction and acute ischemic; * Installation of the pacemaker, intracardiac catheters or operations on the brain, requiring the abandonment of metal objects in the cranial cavity; * Pregnancy; * Enhancement of the patient, which requires the maintenance of vital functions by hardware (mechanical ventilation, continuous application infusomats); * The emergence of an epileptic seizure in response to rhythmic TMS; * Failure of the patient to continue participation in the study;

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors (Lance, 1980). Spasticity - a frequent symptom of neurological diseases (Valero-Cabre, Pascual-Leone, 2005) and may be accompanied by such a disorders consequences of stroke, multiple sclerosis, head trauma and spinal cord, cerebral palsy, etc. The magnitude and severity of spasticity depends on the level of the lesion, the duration of its existence from the time before the disease, and possible plastic changes in axons and synapses on the affected level. There are two basic models of spasticity: cerebral (hemiplegic) and spinal (paraplegicheskaya) (Nikitin, 2005). Cerebral model appears with the direct injury of the brain and is characterized by increased excitability of monosynaptic reflexes with the rapid development of pathological ref-plexes and characteristic hemiplegic posture. Model is characterized by spinal spasticity opposite lower segmental inhibition polysynaptic reflexes slow increase of nervous excitability due to the mechanism of cumulative excitation perevozbuzhdeniem flexor and razgibate-ing, as well as expansion of the area of segmental responses (Nikitin, 2005). As spinal and cerebral spasticity are extremely difficult corrected by standard medical clinic and physiotherapy methods. In this regard, in the world literature actively searched for addi-tional search correct this symptom. A new modern methods that could affect the syndrome of spasticity is rhythmic transcranial magnetic stimulation (Mori et al., 2009).

Papers

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History

    1. Started

      Feb 2013

    2. Main results due

      Sept 2015

    3. Finished

      Dec 2015

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