Influence of High Intensity Exercise on Insulin Resistance, Muscle Con
Rehabilitation in MS: Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Training
What it measured
Main measures
insulin sensitivity (insulin profile)
change from baseline to 12 weeks
muscle contractile properties
from baseline to 12 weeks
Other measures (5)
muscle strength of knee extensor/flexor
change from baseline to 12 weeks
Physical functionaerobic capacity
change from baseline to 12 weeks
Physical functioncytokine profile
change from baseline to 12 weeks
Immune responseSelf-reported measures
Change from baseline to 12 weeks
body composition
Change from baseline to 12 weeks
Physical function
Who could take part
MS (type not specified) · 18 to 65 · EDSS 0.5 to 6
Show the full criteria
Inclusion criteria
* Diagnosed MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) between 0.5 and 6 * Be able to train 5 times in 2 weeks at the University
Exclusion criteria
* Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases (like diabetes type 2) * Having had an relapse in a period of 3 months prior to the start of the intervention period * Having an relapse during the intervention period * Pregnancy and other contra indications for physical activity * Mental disorders
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study is to investigate the effects of a combined training programme and a high intensity interval training programme on insulin resistance, muscle strength/ muscle contractile properties, aerobic capacity and body composition in MS patients. It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
Papers
Results
12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis.Mediators Inflamm · 2016
Results
High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial.PLoS One · 2015
Results
Multiple sclerosis affects skeletal muscle characteristics.PLoS One · 2014
Results
Hansen D, Wens I, Vandenabeele F, Verboven K, Eijnde BO. Altered signaling for mitochondrial and myofibrillar biogenesis in skeletal muscles of patients with multiple sclerosis. Transl Res. 2015 Jul;166(1):70-9. doi: 10.1016/j.trsl.2015.01.006. Epub 2015 Jan 20.
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History
Started
Mar 2013
Main results due
Mar 2014
Finished
Mar 2014