Effects of the Cross-Training in Patients With Multiple Sclerosis
Neurophysiological, Dynamometric, Functional and Clinical Assessment of the Cross-Training Effect in Patients With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Cross-Training multiple sclerosis
Compared with
- Cross-Training healthy subjects
- Standard-training multiple sclerosis
What it measured
Main measures
Muscular strength
Muscular strength will be assessed at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up.
Physical function
Other measures (1)
Neural adaptations to Cross Training
Neural adaptations will be assessed at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up.
Nerve conduction tests
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Age: 18-65 years * Expanded Disability Status Scale (EDSS) ≤6 (Pyramidal functional system ≥3)
Exclusion criteria
* Clinically relevant cognitive disorders; * Disability caused by other diseases; * Medication with corticosteroids within three months prior to enrolment; * Medication with botulinum toxin within six months prior to enrolment; * Clinically or radiologically documented exacerbation within six months prior to enrolment; * Variations in disease-modifying drugs (DMD) within three months prior to enrolment; * Severe ataxia and postural instability (assessed with Berg Balance Scale); * Depression
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer of strength with neurophysiological, functional and clinical correlates, to the contralateral, more-impaired limb.
Papers
Results
Time course of strength adaptations following high-intensity resistance training in individuals with multiple sclerosis.Eur J Appl Physiol · 2017
Results
No evidence of neural adaptations following chronic unilateral isometric training of the intrinsic muscles of the hand: a randomized controlled study.Eur J Appl Physiol · 2016
Results
Manca A, Pisanu F, Ortu E, De Natale ER, Ginatempo F, Dragone D, Tolu E, Deriu F. A comprehensive assessment of the cross-training effect in ankle dorsiflexors of healthy subjects: A randomized controlled study. Gait Posture. 2015 Jun;42(1):1-6. doi: 10.1016/j.gaitpost.2015.04.005. Epub 2015 Apr 20.Results
Morrone M, Martinez G, Achene A, Scaglione M, Masala S, Manca A, Deriu F. Size and site matter: the influence of corpus callosum subregional lesions on the magnitude of cross-education of strength. Front Physiol. 2025 Feb 24;16:1554742. doi: 10.3389/fphys.2025.1554742. eCollection 2025.Results
Manca A, Martinez G, Aiello E, Ventura L, Deriu F. Effect of Eccentric Strength Training on Elbow Flexor Spasticity and Muscle Weakness in People With Multiple Sclerosis: Proof-of-Concept Single-System Case Series. Phys Ther. 2020 Jul 19;100(7):1142-1152. doi: 10.1093/ptj/pzaa055.Results
Manca A, Martinez G, Cereatti A, Della Croce U, Ventura L, Dvir Z, Deriu F. Isokinetic predictors of gait speed increase following high-intensity resistance training of the ankle dorsiflexors in people with multiple sclerosis: A pilot study. Clin Biomech (Bristol). 2019 Jul;67:102-106. doi: 10.1016/j.clinbiomech.2019.05.008. Epub 2019 May 9.Results
Manca A, Cabboi MP, Dragone D, Ginatempo F, Ortu E, De Natale ER, Mercante B, Mureddu G, Bua G, Deriu F. Resistance Training for Muscle Weakness in Multiple Sclerosis: Direct Versus Contralateral Approach in Individuals With Ankle Dorsiflexors' Disparity in Strength. Arch Phys Med Rehabil. 2017 Jul;98(7):1348-1356.e1. doi: 10.1016/j.apmr.2017.02.019. Epub 2017 Mar 23.Results
Manca A, Cabboi MP, Ortu E, Ginatempo F, Dragone D, Zarbo IR, de Natale ER, Mureddu G, Bua G, Deriu F. Effect of Contralateral Strength Training on Muscle Weakness in People With Multiple Sclerosis: Proof-of-Concept Case Series. Phys Ther. 2016 Jun;96(6):828-38. doi: 10.2522/ptj.20150299. Epub 2015 Dec 4.
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History
Started
Jul 2013
Main results due
Mar 2017
Finished
Mar 2017