Safety and Brain Protection Effects of the Green Tea Extract Theapheno
Safety and Neuroprotective Effects of Theaphenon 95% (95% Pure EGCG) in Multiple Sclerosis
What it found
The trial ended early for another reason (see below).
Reason given: unable to enroll
What was tested
Treatment tested
- 95% Pure ECGC capsules 200mg
Placebo
- Placebo Comparator:
What it measured
Main measures
Rate of change in NAA levels adjusted for water content.
6 months
MRI lesionsBlood or spinal fluid markers
Other measures (1)
Brain Atrophy
6 months
Brain volume loss
Who could take part
Relapsing and progressive · 18 to 65
Show the full criteria
Inclusion criteria
* Diagnosis of MS by McDonald criteria * Relapsing-remitting MS or secondary progressive MS * Stable therapy with Copaxone, Rebif, Betaseron or Avonex 30 mcg for at least six months * EDSS Score less than or equal to 7.0 * Ages 18-60. * Participants must have normal organ and marrow function as defined below: * Leukocytes ≥3,000/µL * Absolute neutrophil count ≥1,500/µL * Platelets ≥100,000/µL * Total bilirubin ≤local upper limit of normal * AST (SGOT) ≤local upper limit of normal * ALT (SGPT) ≤local upper limit of normal * Creatinine ≤local upper limit of normal
Exclusion criteria
* MS relapse within the 30 days prior to enrollment * A primary progressive form of MS. * Previous treatment prior to study entry as follows: complete radiation ablation of the bone marrow or anti-CD4 antibody treatment (Campath) at any time; mitoxantrone, cyclophosphamide, Natalizumab or other immunomodulatory or immunosuppressant therapies except the DMT's included in the inclusion criteria and methylprednisone for relapses within prior nine months. * History of renal or liver disease. * Consumption of green tea or supplements containing green tea or tea extract within 30 days prior to enrollment. * Participants may not participate in any other clinical trial involving investigational agents during the study, or within six months prior to enrolling in the study. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to Polyphenon E, tea, or any of the inactive ingredients present in the active or placebo capsules, including gelatin. * History of allergic reactions to gadolinium or any other condition contraindicated for MRI. * Uncontrolled, clinically-relevant active illness (aside from MS) including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Any condition which would make the subject, in the opinion of the investigator, unsuitable for the study * Inability to complete the baseline MRI scan * Pregnant women * Any underlying predisposition to gastrointestinal bleeding (peptic ulcer disease, gastritis, diverticulitis, colitis, hemorrhoids)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The hypothesis is that 95% pure EGCG can protect brain cells in patients with Multiple Sclerosis. To test this hypothesis we are going to compare the changes in n-Acetyl-Aspartate (a chemical that reflects the number of neurons and their metabolism) over one six between people with MS treated with EGCG at a dose of 400mg twice a day and people with MS treated with a matching sugar pill.
Papers
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History
Started
Dec 2015
Main results due
Mar 2017
Finished
Dec 2017