Exercise & Brain Health in MS
Aerobic Exercise to Improve Brain Metabolism in MS
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Aerobic Exercise
Compared with
- Stretching
- Aerobic Exercise- Healthy Subjects
What it measured
Main measures
Comparison of correlations in changes in VO2Max at 12 weeks with changes in brain ATP production at 12 weeks between aerobic exercise group and stretching group.
Baseline, Twelve Weeks
MRI lesionsPhysical function
Other measures (2)
Changes in Cognition at 12 weeks
Baseline, Twelve Weeks
Thinking and memoryChanges in fatigue at 12 weeks
Baseline, Twelve Weeks
Fatigue
Who could take part
Relapsing MS · 18 to 65
Show the full criteria
Inclusion criteria
i. Physician-confirmed diagnosis of relapsing-remitting MS ii. > 18 years old iii. Expanded Disability Status Scale (EDSS) \< 4.0 iv. Able to give informed consent
Exclusion criteria
i. Current cardiopulmonary disease requiring treatment (hypertension permitted) ii. Medical or biophysical conditions that do not permit use of either a cycle ergometer or treadmill iii. MRI contraindications (pacemaker, wires, defibrillator, or implanted heart valves, head surgery requiring aneurysm clips, or any type of electric device (stimulator or pump) implanted in the body) iv. MS exacerbation in the last 30 days v. Pregnant women: Pregnancy status determined by menstrual history and contraceptive method. Confirmatory urine pregnancy test will be used if pregnancy status is uncertain
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study is to learn more about multiple sclerosis (MS). The investigators are studying whether aerobic exercise is better than a stretching program at improving brain health in people with MS. We want to learn: 1. If it is safe and practical for people with MS to participate in an aerobic exercise program with the goal of increasing cardiac fitness. Cardiac fitness is measured with exercise stress tests at the beginning and end of the study. 2. If aerobic exercise improves brain metabolism, a reflection of brain health, more than stretching. Brain metabolism is measured by MRIs at the beginning and end of the study. There is a 50% chance of being in the aerobic exercise or the stretching program. There are between 8 and 36 visits to OHSU, depending on the intervention group. The total duration of the study is at most 21 weeks.
Papers
Results
Effect of High-Intensity Exercise on Multiple Sclerosis Function and Phosphorous Magnetic Resonance Spectroscopy Outcomes.Med Sci Sports Exerc · 2019
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History
Started
Sept 2014
Main results due
Apr 2016
Finished
May 2016