Exercise Intensity and Immune Function in Multiple Sclerosis
Exercise Intensity and Immune Function in Multiple Sclerosis
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- High intensity exericse
- Moderate intensity exericse
What it measured
Main measures
Change in serum brain-derived neurotrophic factor (BDNF) level
Chronic - Baseline, week 7, week 15 and follow-up (week 20). Acute - 15 mins, 30 mins and 1 hour post-exercise
Other measures (11)
Change in serum nerve growth factor (NGF) level
Chronic - Baseline, week 7, week 15 and follow-up (week 20). Acute - 15 mins, 30 mins and 1 hour post-exercise
Change in serum interleukin-4 (IL-4) level
Chronic - Baseline (week 0), week 7, week 15 and follow-up (week 20). Acute - 15 mins, 30 mins and 1 hour post-exercise
Immune responseChange in serum interferon gamma (IFN-γ) level
Chronic - Baseline (week 0), week 7, week 15 and follow-up (week 20). Acute - 15 mins, 30 mins and 1 hour post-exercise
Immune responseChange in mobility
Baseline, weeks 5, 10, 15 and follow up (week 20)
Walking and mobilityChange in exercise capacity
Baseline, weeks 5, 10, 15 and follow up (week 20)
Walking and mobilityPhysical functionChange in fatigue
Baseline, weeks 5, 10, 15 and follow up (week 20)
FatigueChange in health-related quality of life
Baseline, weeks 5, 10, 15 and follow up (week 20)
Quality of life (reported by participants)Change in cognitive ability
Baseline, weeks 5, 10, 15 and follow up (week 20)
Thinking and memoryNumber of sessions attended
15 weeks
Physical functionQuality of life (reported by participants)Change in cardiorespiratory fitness
Baseline and week 15
Physical function
Who could take part
MS (type not specified) · 18 to 60 · EDSS 3.0 to 5.0
Show the full criteria
Inclusion criteria
* Clinically confirmed MS (according to the revised 2010 McDonald criteria) (Polman et al., 2011) * Expanded disability status scale (EDSS) 3.0-5.0
Exclusion criteria
* Unable to consent due cognitive impairment or mental illness * Immunomodulatory therapy in past 3 months * Steroid therapy in the past 6 weeks * Existence of medical contraindications for exercise i.e. cardiovascular or orthopaedic disease. * Compounding neurological condition other than MS
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study aims to determine the effect of exercise intensity within a 15 week programme in moderately disabled people with multiple sclerosis (MS). Although earlier research has shown that exercise is safe and may improve health related factors such as mobility and fatigue, the intensity at which exercise offers the most benefit has not yet been defined. Participants will be randomly assigned to one of three groups - high intensity, moderate intensity or usual care. Participants in the exercising groups (high and moderate intensity) will take part in a supervised 15 week cycling exercise programme based in the Douglas Grant Rehabilitation Centre. Those assigned to the usual care (control) group will continue to receive their usual medical care and will not participate in the exercise programme. The acute immune response to exercise will also be measured. Participants from all three groups will be monitored regularly. Clinical outcomes of the study include immunological markers, exercise capacity, mobility, fatigue, quality of life and cognitive ability. These will be measured by a combination of blood tests, physical assessments and questionnaires. It is hypothesised that high intensity exercise will cause a favourable, anti-inflammatory response which will be associated with greater improvements in physical and psychological outcomes than both moderate intensity exercise and usual care.
Papers
Background
Heine M, Hoogervorst EL, Hacking HG, Verschuren O, Kwakkel G. Validity of maximal exercise testing in people with multiple sclerosis and low to moderate levels of disability. Phys Ther. 2014 Aug;94(8):1168-75. doi: 10.2522/ptj.20130418. Epub 2014 Mar 27.Background
Collett J, Dawes H, Meaney A, Sackley C, Barker K, Wade D, Izardi H, Bateman J, Duda J, Buckingham E. Exercise for multiple sclerosis: a single-blind randomized trial comparing three exercise intensities. Mult Scler. 2011 May;17(5):594-603. doi: 10.1177/1352458510391836. Epub 2011 Jan 19.
Loading reviews and guidelines…
History
Started
Nov 2014
Main results due
Jul 2015
Finished
Jul 2015