Study of Social Cognition by Morphological and Functional Imaging in M
Study of Social Cognition by Morphological and Functional Imaging in Multiple Sclerosis Patients
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Brain MRI - Clinical and cognitive evaluation
- MRI
What it measured
Main measures
Brain activation networks during MRI
At inclusion (day 0)
MRI lesionsThinking and memory
Other measures (2)
Reduction of volume of deep brain structures and reduction of cortical thickness
At inclusion (day 0)
Brain volume lossThinking and memoryWhite matter skeleton on Fractional Anisotropy (FA) maps established by voxel-based.
At inclusion (day 0)
MRI lesionsThinking and memory
Who could take part
Relapsing MS · 18 to 59
Show the full criteria
Inclusion criteria
Inclusion Criteria (patient group): * Aged 18-59 years * Right handed * Fluent French speaker * MS diagnosis according to McDonald criteria (Polman et al., 2005). * Relapsing-remitting MS (RRMS) according to Lublin et al. (1996); * Having signed an informed consent (later than the day of inclusion and before any examination required by research) * Being affiliated to health insurance Inclusion Criteria (healthy control): * Aged 18-59 years * Right handed * Fluent French speaker * Having signed an informed consent (later than the day of inclusion and before any examination required by research) * Being affiliated to health insurance Exclusion Criteria (patient group): * Other progressive neurological disease; * psychiatric comorbidity including severe depression according to Diagnostic and Statistical Manual-IV (DSM-IV), * alcohol or other addiction to toxic, * Expanded Disability Status Scale (EDSS) > 6; disabling visual or motor problems preventing participation to neuropsychological assessments, * relapse since less than one month, * change of disease-modifying therapy or psychotropic drug since less than one month, * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI * Illiteracy, is unable to count or to read * Pregnant or breastfeeding women * Being under guardianship Exclusion Criteria (healthy control): * History of neurological disease; * family history of MS; * psychiatric comorbidity including severe depression according to DSM-IV; * alcohol or other toxic addiction; * psychotropic drugs; known cognitive complaint or neuropsychological affection; * Prior neuropsychological testing with the same tests less than one year * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI * Illiteracy, is unable to count or to read * Pregnant or breastfeeding women * Being under guardianship
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In recent years, studies have brought knowledge of the difficulties of social cognition in Multiple Sclerosis (MS). The brain tissue alteration at the origin of these difficulties in social cognition mechanisms remain poorly understood. Although recent behavioral studies indicated social disturbances in many of these patients, functional studies investigating specific theory of mind in MS are lacking. The use of new techniques for morphological and functional Magnetic Resonance Imaging (MRI) can identify brain activation networks, mapping the achievement and tissue integrity may be related to disorders of social cognition and cognitive. The investigators propose to study social cognition in MS patients using morphological and functional imaging to determine the mechanisms underlying phenomena such as cerebral compensation and its relationship with cognitive impairment.
Papers
Results
Koubiyr I, Dulau-Metras C, Deloire M, Charre-Morin J, Saubusse A, Brochet B, Ruet A. Amygdala network reorganization mediates the theory of mind performances in multiple sclerosis. J Neurosci Res. 2022 Feb;100(2):537-550. doi: 10.1002/jnr.24986. Epub 2021 Nov 19.Results
Dulau C, Deloire M, Diaz H, Saubusse A, Charre-Morin J, Prouteau A, Brochet B. Social cognition according to cognitive impairment in different clinical phenotypes of multiple sclerosis. J Neurol. 2017 Apr;264(4):740-748. doi: 10.1007/s00415-017-8417-z. Epub 2017 Feb 20.
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History
Started
Nov 2015
Main results due
Mar 2017
Finished
Mar 2017