Robot-assisted Gait Training in Patients With Multiple Sclerosis: Effi
Robot-assisted Gait Training in Patients Affected by Multiple Sclerosis: Rehabilitative Efficacy Evaluation and Comparison With Traditional Methods
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Lokomat (Hocoma, Zurich, Switzerland)
Compared with
- Conventional Physiotherapy
What it measured
Main measures
Timed 25 Foot Walk (25FW)
5 weeks
Disability progressionWalking and mobility
Other measures (13)
Timed 10 meter walking test (TWT)
5 weeks
Walking and mobility6 minute walking test (6MWT)
5 weeks
Walking and mobilityTinetti Test (TT)
5 weeks
Walking and mobilityFunctional Ambulation Categories (FAC)
5 weeks
Modified Ashworth scale for lower limbs
5 weeks
SpasticityModified Motricity Index for lower limbs
5 weeks
Physical functionKnee extensor strength (KES)
5 weeks
Physical functionDouble Time Support (DST)
5 weeks
Walking and mobilityStep Length Ratio (SLR)
5 weeks
Walking and mobilityExpanded Disability Status Scale (EDSS)
5 weeks
Disability progression
Who could take part
MS (type not specified) · EDSS 3.5 to 7
Show the full criteria
Inclusion criteria
* diagnosis of multiple sclerosis according to the McDonald's Criteria in stable phase of disease for at least 3 months. * ability to walk 25 foot without assistance * EDSS score between 3.5 and 7
Exclusion criteria
* exacerbations of the disease in the last 3 months * deficits of somatic sensation involving the legs * other neurological, orthopedic or cardiovascular co-morbility * severe posture abnormalities * severe-moderate cognitive impairment (Mini Mental State ≤ 21) * body weight greater than 135 kg; * height more than 200 cm; * limb-length discrepancy greater than 2 cm; * presence of skin lesions on the trunk, pelvis and lower limbs that could interfere with the placement of the electrodes and straps anchoring the Lokomat.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In Multiple Sclerosis (MS) gait disorders represent one of the most disabling aspect that strongly influence patient quality of life. The improvement of walking ability is a primary goal for rehabilitation treatment. Current promising rehabilitative approaches for neurological disorders are based on the concept of the task-specific repetitive training. Hence, the interest in automated robotic devices that allow this typology of treatment for gait training. However, studies on the effectiveness of such methodologies are still poorly numerous in terms of functional improvement in MS patients. The aim of this controlled cross-over study is to evaluate the effectiveness of a Lokomat gait training in patients affected by Multiple Sclerosis in comparison to a ground conventional gait training.
Papers
Results
Robot-Assisted Gait Training in Patients with Multiple Sclerosis: A Randomized Controlled Crossover Trial.Medicina (Kaunas) · 2021
Results
Schwartz I, Sajin A, Moreh E, Fisher I, Neeb M, Forest A, Vaknin-Dembinsky A, Karusis D, Meiner Z. Robot-assisted gait training in multiple sclerosis patients: a randomized trial. Mult Scler. 2012 Jun;18(6):881-90. doi: 10.1177/1352458511431075. Epub 2011 Dec 6.Results
Beer S, Aschbacher B, Manoglou D, Gamper E, Kool J, Kesselring J. Robot-assisted gait training in multiple sclerosis: a pilot randomized trial. Mult Scler. 2008 Mar;14(2):231-6. doi: 10.1177/1352458507082358. Epub 2007 Oct 17.Results
Lo AC, Triche EW. Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training. Neurorehabil Neural Repair. 2008 Nov-Dec;22(6):661-71. doi: 10.1177/1545968308318473.Results
Swinnen E, Beckwee D, Pinte D, Meeusen R, Baeyens JP, Kerckhofs E. Treadmill training in multiple sclerosis: can body weight support or robot assistance provide added value? A systematic review. Mult Scler Int. 2012;2012:240274. doi: 10.1155/2012/240274. Epub 2012 May 30.Results
Vaney C, Gattlen B, Lugon-Moulin V, Meichtry A, Hausammann R, Foinant D, Anchisi-Bellwald AM, Palaci C, Hilfiker R. Robotic-assisted step training (lokomat) not superior to equal intensity of over-ground rehabilitation in patients with multiple sclerosis. Neurorehabil Neural Repair. 2012 Mar-Apr;26(3):212-21. doi: 10.1177/1545968311425923. Epub 2011 Dec 2.Results
Wier LM, Hatcher MS, Triche EW, Lo AC. Effect of robot-assisted versus conventional body-weight-supported treadmill training on quality of life for people with multiple sclerosis. J Rehabil Res Dev. 2011;48(4):483-92. doi: 10.1682/jrrd.2010.03.0035.Results
Pilutti LA, Lelli DA, Paulseth JE, Crome M, Jiang S, Rathbone MP, Hicks AL. Effects of 12 weeks of supported treadmill training on functional ability and quality of life in progressive multiple sclerosis: a pilot study. Arch Phys Med Rehabil. 2011 Jan;92(1):31-6. doi: 10.1016/j.apmr.2010.08.027.Results
Giesser B, Beres-Jones J, Budovitch A, Herlihy E, Harkema S. Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study. Mult Scler. 2007 Mar;13(2):224-31. doi: 10.1177/1352458506070663.Results
Eng J. Sample size estimation: how many individuals should be studied? Radiology. 2003 May;227(2):309-13. doi: 10.1148/radiol.2272012051.
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History
Started
Jun 2014
Main results due
Dec 2015
Finished
Jun 2016