Speed of Processing Training to Improve Cognition in Multiple Sclerosis: A Randomized Clinical Trial

CompletedNot a drug-phase studyMS (type not specified)NCT02301260

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Speed of Processing Training (SPT)

Placebo

  • Placebo Control

What it measured

Main measures

  • Change in scores on standardized tests of processing speed

    Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed

    Thinking and memory

Other measures (3)

  • Change in scores on self-report of emotional functioning, measured via questionnaire

    Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed

  • Change in scores on self-report of everyday functioning, measured via questionnaire

    Three points in time: pre-treatment, immediately following treatment and 6 months after treatment is completed

  • Change in scores on self-report of quality of life, measured via questionnaire

    Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed

    Quality of life (reported by participants)

Who could take part

MS (type not specified) · 18 to 59

Show the full criteria

Inclusion criteria

* English as a primary language * diagnosis of Multiple Sclerosis * processing speed impairment (based on evaluation)

Exclusion criteria

* most recent exacerbation within one month * currently taking steroids or benzodiazepines * history of significant psychiatric illness (bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder * significant alcohol or drug abuse history

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The purpose of this research study is to investigate the effectiveness of a computerized technique designed to improve processing speed (i.e. the amount of time it takes for a person's brain to process information) in a multiple sclerosis (MS) population. The study is designed to study how well this technique can help people with MS increase their processing speed and their ability to function better in everyday life. This treatment protocol has been studied extensively with older adults, showing improvements on standard laboratory measures of processing speed and performance of activities of daily living.

Papers

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History

    1. Started

      Apr 2014

    2. Main results due

      Feb 2020

    3. Finished

      Feb 2020

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