Baseline Cortical Haemodynamics in MS
Investigating Baseline Cortical Haemodynamics in Multiple Sclerosis
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Magnetic Resonance Imaging
Given for the study's measurements
- Gadoteridol
Diagnostic agent
What it measured
Main measures
Cerebral Blood Flow
1 hour
MRI lesions
Other measures (2)
Arterial Cerebral Blood Volume
1 hour
MRI lesionsArterial Transit Time
1 hour
MRI lesions
Who could take part
MS (type not specified) · 21 to 80
Show the full criteria
Inclusion criteria
Inclusion Criteria (Healthy Volunteers): * Male or female volunteers who are between the ages of 21 and 80. * Able to give voluntary written informed consent to participate in the study. * Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures. Inclusion Criteria (Patients): * Diagnosed with Multiple Sclerosis. * Male or female volunteers who are between the ages of 21 and 80. * Able to give voluntary written informed consent to participate in the study. * Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures.
Exclusion criteria
* Any history of neurological illness other than MS. * Known hypersensitivity to any MR or X-Ray contrast agent. * Any history of renal failure or disease. * Any history of allergies. * Any history of circulation problems (vascular disease). * Pregnancy or breastfeeding. * MRI contraindications as screened on safety questionnaire (e.g. metal implants or pacemaker). * Have taken part in any other clinical study within the previous 3 months.# * Any contraindications provided from MRI or contrast agent safety forms.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease. It will also instruct us as to the most effective scanning protocols for future research. Developing a suitable protocol for studying perfusion longitudinally may also enable identification of new therapeutic interventions to normalise any perfusion abnormalities in MS patients.
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History
Started
Jan 2017
Main results due
Oct 2019
Finished
Oct 2019