Online Cognitive Training in PD, MS and Depressed Patients Treated Wit
Clinical Pilot Study in the Feasibility and Effect of Online Cognitive Training on Cognitive Functions in Patients With Parkinson's Disease, Multiple Sclerosis and Depressive Patients Treated With Electroconvulsive Therapy
What it found
The trial ended early for another reason (see below).
Reason given: All Parkinson's disease patients have finished training. The MS and ECT groups have not finished as these groups had trouble including 20 patients.
This trial finished 9 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Online cognitive training
Compared with
- Active control condition
What it measured
Main measures
Feasibility
8 weeks
MRI lesionsFeasibility
Other measures (7)
Trail Making Task
Baseline, 8 weeks and 12 weeks
MRI lesionsThinking and memoryCognitive functioning (subjectively measured)
Baseline, 8 weeks and 12 weeks
Thinking and memoryFeasibility
Patients will be interviewed in a group session after study completion, an expected average of half a year
FeasibilityStroop Color Word Task
Baseline, 8 weeks and 12 weeks
MRI lesionsThinking and memoryLetter Fluency
Baseline, 8 weeks and 12 weeks
MRI lesionsThinking and memoryRey Auditory Verbal Learning Test
Baseline, 8 weeks and 12 weeks
MRI lesionsThinking and memoryLocation Learning Test
Baseline, 8 weeks and 12 weeks
MRI lesionsThinking and memory
Who could take part
MS (type not specified) · 30 to 70
Show the full criteria
Inclusion criteria
General criteria: * Patients have (access to) a computer with access to the Internet. Patients are capable of using a keyboard and computer mouse. * Patients are willing to sign informed consent. PD-specific criteria: * A compilation score of executive functions (i.e. Stroop, Trail Making Task, Fluency) shows deficit, which lies between 1 and 2 standard deviation (SD) below the mean of healthy Dutch norm population. * Patients are diagnosed with Parkinson's disease according to the United Kingdom Parkinson's Disease Society Brain Bank criteria. * Patients are in Hoehn \& Yahr stadium \< 4, and are medically stable during a month prior to the intervention. The medication will be attempted to remain stable for the remainder of the intervention. * Patients are 50 to 70 years old. MS-specific criteria: * A compilation score of episodic memory (i.e. Rey Auditory Verbal Learning Test, Location Learning Test) shows deficit, which lies between 1 and 2 SD below the mean of healthy norm population. * Patients have been diagnosed with MS for a period longer than three month prior to inclusion in this study according to the renewed McDonald criteria. * Patients have been on stable medication for at least three months. * Patients are 30 to 45 years old. PostECT-specific criteria: * Unipolar depressive patients indicated for ECT, who experience cognitive complaints after treatment with ECT. * Patients have undergone the full ECT-procedure. * Phonemic fluency and autobiographical memory (measured by the Kopelman Autobiographical Interview) show deficit: significant individual deterioration is present (> 1.5 SD deterioration), accounting for test- retest effects. * Patients are 50 to 70 years old.
Exclusion criteria
General criteria: * Indications for presence of dementia. * Presence of traumatic brain injury. * A psychiatric disorder (in the postECT group: other than unipolar depression). * No history or presence of drug or alcohol abuse. * Inability to undergo a neuropsychological assessment (e.g. due to fast fatigue, seeing problems or language barrier). PD-specific criteria: - Psychotic symptoms, as screened by the Questionnaire for Psychotic Experiences (QPE). Benign hallucinations with insight are not contraindicated). MS-specific criteria: - Patients with MS can't have relapses or can't use corticosteroids 4 weeks prior to the start of the study. postECT-specific criteria: - Indications for presence of delirium.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In Parkinson's disease, Multiple Sclerosis and depressed patients treated with electroconvulsive therapy, cognitive dysfunction is prevalent. However, treatment of these dysfunctions is in its infancy. The purpose of this study is 1) to assess the feasibility of a randomized controlled trial using an online computerized intervention for training cognitive abilities in the three patient groups and 2) to estimate the effect of the online training on objectively and subjectively measured cognitive functions. The investigators hypothesize that patients using online cognitive training will improve more on cognitive functions, as compared to patients using an active control condition.
Papers
Background
Oudega ML, van Exel E, Wattjes MP, Comijs HC, Scheltens P, Barkhof F, Eikelenboom P, de Craen AJ, Beekman AT, Stek ML. White matter hyperintensities and cognitive impairment during electroconvulsive therapy in severely depressed elderly patients. Am J Geriatr Psychiatry. 2014 Feb;22(2):157-66. doi: 10.1016/j.jagp.2012.08.002. Epub 2013 Jan 11.Background
Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 2008 Dec;7(12):1139-51. doi: 10.1016/S1474-4422(08)70259-X.Background
Bosboom JL, Stoffers D, Wolters ECh. Cognitive dysfunction and dementia in Parkinson's disease. J Neural Transm (Vienna). 2004 Oct;111(10-11):1303-15. doi: 10.1007/s00702-004-0168-1. Epub 2004 Jun 30.Background
Rubin EH, Kinscherf DA, Figiel GS, Zorumski CF. The nature and time course of cognitive side effects during electroconvulsive therapy in the elderly. J Geriatr Psychiatry Neurol. 1993 Apr-Jun;6(2):78-83. doi: 10.1177/089198879300600204.Background
Achiron A, Barak Y. Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry. 2003 Apr;74(4):443-6. doi: 10.1136/jnnp.74.4.443.Background
Muslimovic D, Post B, Speelman JD, Schmand B. Cognitive profile of patients with newly diagnosed Parkinson disease. Neurology. 2005 Oct 25;65(8):1239-45. doi: 10.1212/01.wnl.0000180516.69442.95.Background
Aarsland D, Andersen K, Larsen JP, Lolk A, Kragh-Sorensen P. Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol. 2003 Mar;60(3):387-92. doi: 10.1001/archneur.60.3.387.Background
Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord. 2008 Apr 30;23(6):837-44. doi: 10.1002/mds.21956.Background
Rao SM, Leo GJ, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology. 1991 May;41(5):685-91. doi: 10.1212/wnl.41.5.685.Background
Klepac N, Trkulja V, Relja M, Babic T. Is quality of life in non-demented Parkinson's disease patients related to cognitive performance? A clinic-based cross-sectional study. Eur J Neurol. 2008 Feb;15(2):128-33. doi: 10.1111/j.1468-1331.2007.02011.x.
Loading reviews and guidelines…
History
Started
Mar 2016
Main results due
Jun 2017
Finished
Jul 2017