Lakeshore Examination of Activity and Disability Exercise Response Stu

Dose-Response Effects of Transformative Exercise in Improving Health and Function in Adults With Spinal Cord Injury and Multiple Sclerosis

CompletedNot a drug-phase studyMS (type not specified)NCT02533882

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Movement to Music

Compared with

  • Adapted Yoga

What it measured

Main measures

  • Cardiorespiratory Fitness as measured by sub-maximal VO2

    12 weeks

    Walking and mobilityPhysical function

  • Pain as measured by PROMIS Pain Interference Short Form 8a

    12 weeks

    Pain

  • Fatigue as measured by PROMIS Fatigue Short Form 8a

    12 weeks

    Fatigue

  • Loneliness as measured by the Three-Item Loneliness Scale

    12 weeks

  • Grip Strength as measured by hand grip dynamometer

    12 weeks

    Arm and hand functionPhysical function

  • Strength as measured by Biodex System 3 Multijoint dynamometer

    12 weeks

    Physical function

  • Balance as measured by the Timed Up and Go

    12 weeks

    Walking and mobility

  • Balance as measured by Biodex Limits of Stability

    12 weeks

    Walking and mobility

  • Balance as measured by Repeated Chair Stands

    12 weeks

    Walking and mobility

Other measures (14)

  • Health Biomarkers as measured by blood analysis (insulin)

    12 weeks

    Blood or spinal fluid markers

  • Health Biomarkers as measured by blood analysis (lipids)

    12 weeks

    Blood or spinal fluid markers

  • Health Biomarkers as measured by blood analysis (fasting glucose)

    12 weeks

    Blood or spinal fluid markers

  • Blood pressure

    12 weeks

  • Anthropometric measurements (weight)

    12 weeks

  • Circumference measurements to be reported as composite ratios (waist circumference, hip circumference, neck circumference)

    12 weeks

  • Physical Function with Mobility Aid as measured by PROMIS Physical Function with Mobility Aid 455b

    12 weeks

    Walking and mobility

  • Anxiety as measured by PROMIS Emotional Distress-Anxiety Short Form 8a

    12 weeks

    Mood and sleep

  • Depression as measured by PROMIS Emotional Distress-Depression Short Form 8a

    12 weeks

    Mood and sleep

  • Sleep Disturbance as measured by PROMIS Sleep Disturbance Short Form 8a

    12 weeks

    Mood and sleep

Who could take part

MS (type not specified) · 18 to 65

Show the full criteria

Inclusion criteria

* Diagnosed with stroke * MS - mild to moderate disability (Patient Determined Disease Steps Score 0-6) * Able to use arms or arms/legs for exercise * Ambulatory or use manual wheelchair

Exclusion criteria

* Cognitive impairment (Mini-Mental State Exam score \< 24) * Recent weight change (+/- 25 pounds in 1 year) * Poorly controlled blood pressure * Cardiovascular disease event within the past six months * Severe pulmonary disease * Renal failure * Current tobacco user or quit within the last six months * Current use of medications for psychosis * Active pressure ulcers

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study will examine the effectiveness of two types of group exercise classes on the health and functional status in inactive adults age 18-65 with neurological conditions including Multiple Sclerosis, stroke, and spinal cord injury (SCI). Participants will be randomly assigned to one of three groups; Movement to Music, Adapted Yoga, or a waitlist group who will complete a home-based exercise intervention of either Movement to Music or Adapted Yoga.

Papers

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History

    1. Started

      Dec 2014

    2. Main results due

      Jul 2019

    3. Finished

      Aug 2019

    Assembled by software from public sources.