tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
Transcranial Direct Current Stimulation and Cognition in Adults With Multiple Sclerosis or Encephalitis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Anodal Transcranial direct current stimulation
Placebo
- Sham Transcranial direct current stimulation
Results by group
Change in Cognition as Assessed by Change in Paced Auditory Serial Addition Test Scores
Assessed at beginning and end of a 5-day treatment week
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Sham tDCS | -1.20 score on a scale | 6.26 (Standard Deviation) | 5 |
| Active Anodal tDCS | -0.33 score on a scale | 9.42 (Standard Deviation) | 6 |
Sham tDCS
Active Anodal tDCS
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Sham tDCS | 6 | 0 (0.0%) | 0 |
| Active Anodal tDCS | 7 | 0 (0.0%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Change in Cognition as Assessed by Change in Paced Auditory Serial Addition Test Scores
Assessed at beginning and end of a 5-day treatment week
Thinking and memory
Other measures (1)
Change in Fatigue as Assessed by Multidimensional Fatigue Symptom Inventory 30-item Short Form (MFSI-SF) Total Scores
Assessed at beginning and end of a 5-day treatment week
Fatigue
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Diagnosis of multiple sclerosis or encephalitis * Over the age of 18
Exclusion criteria
* A diagnosis of schizophrenia bipolar disorder * Beck Depression Inventory-II scores over 20 * Mini Mental Exam below 24 * Any uncontrolled seizure disorder * Any implanted metal device or hearing aids * Use of medication shown to interact with tDCS effectiveness
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis. Participants will be asked to come in daily for two full weeks during which time participants will undergo cognitive testing and Magnetic Resonance Imaging (MRI) brain scans. In this research, a very weak electrical current is administered to the surface of the scalp while participants complete cognitive tasks. The investigators' aim is to find out whether tDCS will improve task performance in adults with multiple sclerosis or encephalitis.
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History
Started
Sept 2014
Main results due
Jun 2019
Finished
Jun 2019
Results posted
Apr 2020