Effects of Stimulation Patterns of Deep Brain Stimulation
Effects of Stimulation Patterns of Deep Brain Stimulation
What it found
No result yet.
What was tested
Treatment tested
- Therapeutic Stimulation Patterns
- Symptogenic Stimulation Patterns
What it measured
Main measures
Tremor Accelerometry
Day 1
Physical functionBradykinesia Finger Tapping
Day 1
Physical functionNeural Activity
Day 1
Myelin repairPhysical function
Other measures (1)
Electrode Location
Day 1
Who could take part
MS (type not specified) · 21 to 80
Show the full criteria
Inclusion criteria
* Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) dystonia or Multiple Sclerosis (MS) * Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant, IPG implant or implanted pulse generator (IPG) replacement surgery * Neurologically stable * Able to understand the study and consent form
Exclusion criteria
* Inability to execute the motor tasks during the study * Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications * Clinically ineffective DBS
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia or multiple sclerosis (MS). These data will guide the design of novel stimulation patterns that may lead to more effective and reliable treatment with DBS. These data will also enable evaluation of current hypotheses on the mechanisms of action of DBS. Improving our understanding of the mechanisms of action of DBS may lead to full development of DBS as a treatment for Parkinson's disease and may lead to future applications of DBS.
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History
Started
Jun 2016
Main results due
Mar 2027
Finished
Mar 2027