Study by Magnetic Resonance Imaging in the Progressive Forms of Multip
Study by Magnetic Resonance Imaging of the Modifications of the Vasoreactivity and Cerebral Connectivity in the Progressive Forms of Multiple Sclerosis
What it found
The trial ended early for another reason (see below).
Reason given: Inclusion period ended
This trial finished 9 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Neuropsychological assessment
- Neurologic consultation
- MRIs (with vasoreactivity testing)
What it measured
Main measures
Cerebral vasoreactivity measured by diffusion imaging MRI (quantitative variable) :parameter which allow us to estimate the organization of the white matter tracts
2 months
MRI lesions
Other measures (2)
Comparison of fonctional connective cards at Resting state
2 months
Cognitive disorders
2 months
Thinking and memory
Who could take part
Relapsing and progressive · 30 to 50
Show the full criteria
Inclusion criteria
* For Both patients and healthy volunteers : * Age limits ≥ 30 et ≤ 50 years * Subject able to understand the nature, the aim and the methodology of the study. * Collection of the informed consent * Affiliation or recipient with the mode of social security. * For the patients : * Suffering from progressive multiple sclerosis (primary progressive forms or secondary progressive forms) OR * Suffering from relapsing-remitting multiple sclerosis
Exclusion criteria
* For Both patients and healthy volunteers : * Systemic pathology with neurological manifestations * Antecedent of psychiatric disorders including psychosis (Except anxious depressive disorder) * Subject presenting contraindications in MRI (Ferromagnetic foreign bodies, pace-maker) * Claustrophobia * Women pregnant or Breast-feeding * Person with majority age protected by the law (supervision, trusteeship or under safeguard of justice). * Subject unable to understand the nature and the aim of the study and/or communication difficulties with investigator * Antecedent of serious cranial trauma (according to classification) of ischaemic stroke ou intracranial hematoma. * For the patients : * Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease other than multiple sclerosis * Recent relapse of multiple sclerosis * For the healthy volunteers : * Antecedent of serious cranial trauma (according to classification), anterior or evolutive neurologic disease * Antecedent of neurological disease * In period of exclusion relative to another protocol or which the annual amount of the allowances maximum of 4500 € was reached.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The goal of this study is to show pattern differences of vasoreactivity and connectivity between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these differences with Clinical disability and cognitive disorder results.
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History
Started
Jun 2014
Main results due
Feb 2017
Finished
Feb 2017