Aerobic Exercise and Brain Health in Multiple Sclerosis
Effects of Aerobic Exercise on Brain Health in People With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Aerobic exercise
What it measured
Main measures
Percentage brain volume change
0, 24 and 48 weeks
Brain volume loss
Other measures (11)
Cognition measured by the Brief Repeatable Battery of Neuropsychological Tests
0, 24 and 48 weeks
Thinking and memoryBlood samples: Cytokines and neurotrophins
0, 24 and 48 weeks
Immune responseVO2max
0, 24 and 48 weeks
Physical functionRegional volume change changes (e.g. hippocampus, thalamus)
0, 24 and 48 weeks
Modified Fatigue Impact Scale
0, 24 and 48 weeks
FatigueFatigue Severity Scale
0, 24 and 48 weeks
FatigueMajor Depression Inventory
0, 24 and 48 weeks
Mood and sleepShort Form 36
0, 24 and 48 weeks
Multiple Sclerosis Impact Scale 29
0, 24 and 48 weeks
6-min walk test
0, 24 and 48 weeks
Walking and mobility
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
* Signed consent * Definite MS diagnosis * Be clarified with the diagnosis and treatment * Expectedly able to carry out the aerobic training / test * Expanded Disability Status Scale (EDSS) score ≤6.0 * Must be able to transport themselves to and from training sessions
Exclusion criteria
* Dementia, alcohol abuse or pacemaker * Medical comorbidity such as cardiovascular, respiratory, orthopedic or metabolic disorders or other concurrent diseases causing disability and hindering participation in the intervention * Disease relapse in a 8 week period prior to study start * Pregnancy * Metallic implants hindering the MRI scans. * Expected training attendance below 85%
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of the project is to investigate how aerobic exercise affects brain volume, specific brain regions, neurotrophins and cognition in patients with multiple sclerosis. The study will be a single blinded randomized controlled trial with a 6 months intervention. It is hypothesized that aerobic exercise can slow down brain atrophy, increase the size of hippocampus, upregulate the secretion of neurotrophins and improve cognitive performance in people with multiple sclerosis.
Papers
Results
Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis.Neurology · 2021
Results
Kupjetz M, Langeskov-Christensen M, Riemenschneider M, Inerle S, Ligges U, Gaemelke T, Patt N, Bansi J, Gonzenbach RR, Reuter M, Rosenberger F, Meyer T, McCann A, Ueland PM, Eskildsen SF, Nygaard MKE, Joisten N, Hvid L, Dalgas U, Zimmer P. Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study. Neurol Neuroimmunol Neuroinflamm.Results
Langeskov-Christensen M, Hvid LG, Jensen HB, Nielsen HH, Petersen T, Stenager E, Hamalainen P, Dalgas U. Efficacy of high-intensity aerobic exercise on cognitive performance in people with multiple sclerosis: A randomized controlled trial. Mult Scler. 2021 Sep;27(10):1585-1596. doi: 10.1177/1352458520973619. Epub 2020 Nov 24.
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History
Started
Jan 2016
Main results due
Aug 2018
Finished
May 2019