Task-oriented Upper Limb Training in MS
Intensity Dependent Clinical Effects of a Task-oriented Upper Limb Training in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Task-oriented upper limb training
Compared with
- Control intervention
What it measured
Main measures
Nine Hole peg test
8 weeks
Arm and hand functionManual Ability Measure-36
8 weeks
Isometric hand grip
8 weeks
Arm and hand functionTraining tolerance
daily through study compeletion
Safetypinch grip strength
8 weeks
Arm and hand functionPhysical function
Other measures (10)
Motricity Index
8 weeks
Physical functionMuscle fatigue indices
8 weeks
FatigueArm and hand functionTactile sensitivity in the fingers Semmens-Weinstein monofilaments
8 weeks
Rydel Seiffer Tuning fork
8 weeks
Arm and hand functionSymbol digit modalities test
8 weeks
Thinking and memoryBox and block test
8 weeks
Arm and hand functionAction Research Arm Test
8 weeks
Arm and hand functionTest d'Évaluation des Membres Supérieurs des Personnes Âgées (TEMPA)
8 weeks
Arm and hand functionVirtual Peg Insertion Test
8 weeks
Arm and hand functionAccelerometers (Actigraph)
8 weeks
Arm and hand function
Who could take part
Progressive MS · 18 to 90
Show the full criteria
Inclusion criteria
* Age > 18 years * Diagnosis of MS (McDonald criteria) * Progressive type of MS (primary or secondary progressive MS) * A score 1 or more on the performance scale: item hand function
Exclusion criteria
* A relapse or relapse-related treatment within the last 3 months prior to the study * Complete paralysis of both upper limbs * Marked or severe intention tremor (Fahn's tremor rating scale > 3) * Other medical conditions interfering with the upper limb function (ortopaedic or rheumatoid impairment) * Severe cognitive or visual deficits interfering with testing and training
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
An adequate upper limb function is crucial to independently perform Activities of Daily Living (ADL). Persons with neurological diseases often experience upper limb dysfunction. Upper limb function in Multiple Sclerosis (MS) is highly prevalent, increasing with overall disability level, while the detrimental impact on ADL is higher than in stroke, given that symptoms often occur bilaterally. In contrast to stroke, it is unknown whether similar rehabilitation principles and effect sizes apply in MS given that this progressive neurodegenerative disease is characterized by multiple lesions and atrophy of brain structures. To date, optimal therapy dosage of upper limb rehabilitation programs are not known in the MS literature neither were characteristics of responders identified. The aim of this explorative study is to investigate the intensity dependent clinical effects of a task-oriented upper limb training in persons with MS with different upper limb disability levels.
Papers
Results
Intensity-dependent clinical effects of an individualized technology-supported task-oriented upper limb training program in Multiple Sclerosis: A pilot randomized controlled trial.Mult Scler Relat Disord · 2019
Background
Lamers I, Maris A, Severijns D, Dielkens W, Geurts S, Van Wijmeersch B, Feys P. Upper Limb Rehabilitation in People With Multiple Sclerosis: A Systematic Review. Neurorehabil Neural Repair. 2016 Sep;30(8):773-93. doi: 10.1177/1545968315624785. Epub 2016 Jan 7.Background
Severijns D, Octavia JR, Kerkhofs L, Coninx K, Lamers I, Feys P. Investigation of Fatigability during Repetitive Robot-Mediated Arm Training in People with Multiple Sclerosis. PLoS One. 2015 Jul 27;10(7):e0133729. doi: 10.1371/journal.pone.0133729. eCollection 2015.Background
Feys P, Coninx K, Kerkhofs L, De Weyer T, Truyens V, Maris A, Lamers I. Robot-supported upper limb training in a virtual learning environment : a pilot randomized controlled trial in persons with MS. J Neuroeng Rehabil. 2015 Jul 23;12:60. doi: 10.1186/s12984-015-0043-3.Background
Alt Murphy M, Resteghini C, Feys P, Lamers I. An overview of systematic reviews on upper extremity outcome measures after stroke. BMC Neurol. 2015 Mar 11;15:29. doi: 10.1186/s12883-015-0292-6.Background
Bertoni R, Lamers I, Chen CC, Feys P, Cattaneo D. Unilateral and bilateral upper limb dysfunction at body functions, activity and participation levels in people with multiple sclerosis. Mult Scler. 2015 Oct;21(12):1566-74. doi: 10.1177/1352458514567553. Epub 2015 Feb 6.Background
Severijns D, Lamers I, Kerkhofs L, Feys P. Hand grip fatigability in persons with multiple sclerosis according to hand dominance and disease progression. J Rehabil Med. 2015 Feb;47(2):154-60. doi: 10.2340/16501977-1897.Background
Lamers I, Cattaneo D, Chen CC, Bertoni R, Van Wijmeersch B, Feys P. Associations of upper limb disability measures on different levels of the International Classification of Functioning, Disability and Health in people with multiple sclerosis. Phys Ther. 2015 Jan;95(1):65-75. doi: 10.2522/ptj.20130588. Epub 2014 Sep 4.Background
Lamers I, Feys P. Assessing upper limb function in multiple sclerosis. Mult Scler. 2014 Jun;20(7):775-84. doi: 10.1177/1352458514525677. Epub 2014 Mar 24.Background
Lamers I, Kelchtermans S, Baert I, Feys P. Upper limb assessment in multiple sclerosis: a systematic review of outcome measures and their psychometric properties. Arch Phys Med Rehabil. 2014 Jun;95(6):1184-200. doi: 10.1016/j.apmr.2014.02.023. Epub 2014 Mar 13.
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History
Started
Jan 2016
Main results due
Mar 2018
Finished
Mar 2018