Online Program to Reduce Depression in MS
International Deprexis Trial in Multiple Sclerosis (IDEMS) - a Multicenter Randomized Controlled Trial
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Deprexis, DeprexisPlus
What it measured
Main measures
Beck Depression Inventory-II
Month 0 to Month 3
Mood and sleep
Other measures (4)
WHO Quality of Life scale (WHO-QOL BREF)
Month 0 to Month 3
Quality of life (reported by participants)Multiple Sclerosis Impact Scale (MSIS)
Month 0 to Month 3
Quality of life (reported by participants)Fatigue Scale for Motor and Cognitive Functions (FSMC)
Month 0 to Month 3
Thinking and memoryFatigueChalder Fatigue Scale
Month 0 to Month 3
Fatigue
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* age > 18 * neurologist-confirmed diagnosis of MS (all forms) * self-reported depressive symptoms (BDI-Fastscreen > 4) * fluent in German or English (depending on study site), * willingness to engage in self-administration of an iCBT intervention for 3 months and complete follow-up * ability to travel to the outpatient center for two clinical assessments (baseline and month 3) * internet access at home
Exclusion criteria
* unwilling or unable to consent, * diagnosis of bipolar or psychosis (as determined by M.I.N.I structured interview), * substantial neurocognitive impairments such as dementia or autism * moderate or high risk of suicide (according to MINI module C) or by clinical impression * very severe depression that would interfere with the ability to participate in the study (based on clinical judgment by the physician at the recruitment site). * current psychotherapy/behavioral treatments for depression * started pharmacotherapy for depression within the last 2 months * MS relapse or steroid treatment in the last 4 weeks * concurrent participation in another clinical trial that includes an intervention * refusal to saving, processing and forwarding of pseudonymized data
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This is an international, multicenter, randomized controlled trial of an internet-based CBT intervention for depression (Deprexis) conducted in five MS centers in the US and Germany. The trial consists of a three-arm primary trial phase and an extension phase targeted at maintenance.
Papers
Loading reviews and guidelines…
History
Started
Feb 2017
Main results due
Jan 2021
Finished
May 2021