How Does Strength Training and Balance Training Affect Gait Function a
How Does Strength Training and Balance Training Affect Gait Function and Fatigue in Patients With Multiple Sclerosis?
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Balance training
- Strength training
What it measured
Main measures
Change in gait speed measured by "Six Spot Step Test"
At baseline and again after 10 weeks
Walking and mobilityChange in gait speed measured by "Timed 25 Foot Walk"
At baseline and again after 10 weeks
Disability progressionWalking and mobility
Other measures (8)
Fatigue
At baseline and after 10 weeks
FatigueEndurance
At baseline and after 10 weeks
Walking and mobilitySelf-evaluated gait function
At baseline and after 10 weeks
Walking and mobilityTemporospatial measures
At baseline and after 10 weeks
Walking and mobilityBalance - static
At baseline and after 10 weeks
Walking and mobilityBalance - functional
At baseline and after 10 weeks
Walking and mobilityBalance - confidence
At baseline and after 10 weeks
Walking and mobilityStrength
At baseline and after 10 weeks
Physical function
Who could take part
MS (type not specified) · 18 and over · EDSS 2.0 to 6.5
Show the full criteria
Inclusion criteria
* Diagnosed with multiple sclerosis. * Expanded Disability Status Scale (EDSS) 2.0-6.5 and min. 2.0 in the functional system "pyramidal function". * Able to walk 100 m. * Able to manage own transportation in relation to weekly training and tests. * Six spot step test score > 8 sec. or Timed 25 foot walk > 5 sec.
Exclusion criteria
* Co-morbidity in terms of dementia and alcohol abuse. * Attack within the last eight weeks. * Systematic intensive rehabilitation/training within the last three months. * Adjustment of medication within two months before inclusion. This applies only for medication that affects gait performance and spasticity.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Introduction: Multiple sclerosis (MS) is characterized by decreased strength and motor control, and compromised gait function. Reduced walking speed, balance, and fatigue are the cardinal symptoms. In rehabilitation, strength and balance training are commonly used. There is increasing scientific support of strength training for improving walking function. The evidence for balance training remains flawed. It is known that neurological damage in MS leads to increased cognitive processing in the planning of movements, which predisposes fatigue. Since fatigue is also associated with impaired balance, it can be hypothesized that motoric/balance training with an emphasis on cognitive load can affect gait and fatigue. Purpose: The aim of the study is to determine whether there is a differentiated effect between strength and balance training measured by motor function, strength, balance, and fatigue.
Papers
Results
How does strength training and balance training affect gait and fatigue in patients with Multiple Sclerosis? A study protocol of a randomized controlled trial.NeuroRehabilitation · 2018
Background
Boes MK, Sosnoff JJ, Socie MJ, Sandroff BM, Pula JH, Motl RW. Postural control in multiple sclerosis: effects of disability status and dual task. J Neurol Sci. 2012 Apr 15;315(1-2):44-8. doi: 10.1016/j.jns.2011.12.006. Epub 2012 Jan 10.Background
Claros-Salinas D, Dittmer N, Neumann M, Sehle A, Spiteri S, Willmes K, Schoenfeld MA, Dettmers C. Induction of cognitive fatigue in MS patients through cognitive and physical load. Neuropsychol Rehabil. 2013;23(2):182-201. doi: 10.1080/09602011.2012.726925. Epub 2012 Nov 16.Background
Penner IK, Bechtel N, Raselli C, Stocklin M, Opwis K, Kappos L, Calabrese P. Fatigue in multiple sclerosis: relation to depression, physical impairment, personality and action control. Mult Scler. 2007 Nov;13(9):1161-7. doi: 10.1177/1352458507079267.Background
Andreasen AK, Stenager E, Dalgas U. The effect of exercise therapy on fatigue in multiple sclerosis. Mult Scler. 2011 Sep;17(9):1041-54. doi: 10.1177/1352458511401120. Epub 2011 Apr 5.Background
Corporaal SH, Gensicke H, Kuhle J, Kappos L, Allum JH, Yaldizli O. Balance control in multiple sclerosis: correlations of trunk sway during stance and gait tests with disease severity. Gait Posture. 2013 Jan;37(1):55-60. doi: 10.1016/j.gaitpost.2012.05.025. Epub 2012 Aug 5.Background
Kelleher KJ, Spence W, Solomonidis S, Apatsidis D. The characterisation of gait patterns of people with multiple sclerosis. Disabil Rehabil. 2010;32(15):1242-50. doi: 10.3109/09638280903464497.Background
Hebert JR, Corboy JR. The association between multiple sclerosis-related fatigue and balance as a function of central sensory integration. Gait Posture. 2013 May;38(1):37-42. doi: 10.1016/j.gaitpost.2012.10.015. Epub 2012 Nov 28.Background
Motl RW, Pilutti LA. The benefits of exercise training in multiple sclerosis. Nat Rev Neurol. 2012 Sep;8(9):487-97. doi: 10.1038/nrneurol.2012.136. Epub 2012 Jul 24.Background
Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen HJ, Knudsen C, Overgaard K, Ingemann-Hansen T. Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology. 2009 Nov 3;73(18):1478-84. doi: 10.1212/WNL.0b013e3181bf98b4.
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History
Started
Jun 2016
Main results due
Dec 2018
Finished
Dec 2018