The Effect of High Intensity Interval Training on Cardiovascular Fitne
The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis.
What it found
We found no results in the registry or in papers.
This trial finished 9 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- High intensity interval training
Compared with
- Continuous moderate exercise
What it measured
Main measures
heart rate max
8 weeks
Other measures (10)
Resting blood pressure
8 weeks
Resting heart rate
8 weeks
Brain derived neurotrophic factor
8 weeks
Lactate
8 weeks
Physical functionLipoprotein profile
8 weeks
MSIS-29 version 2
8 weeks
Quality of life (reported by participants)Hospital anxiety and depression scale
8 weeks
Mood and sleepTimed 25 foot walk test
8 weeks
Disability progressionWalking and mobilitySymbol digit modalities test
8 weeks
Thinking and memoryFatigue severity scale
8 weeks
Fatigue
Who could take part
Progressive MS · 18 and over · EDSS 4 to 6.0
Show the full criteria
Inclusion criteria
* Diagnosed with a progressive form of MS * Aged 18 years or older * Known to members of staff of the MS service NHS Ayrshire \& Arran * Ability to attend Douglas Grant Rehabilitation centre twice a week for eight weeks * EDSS 4-6.0 * Able to cycle on ergometer
Exclusion criteria
* A relapse of symptoms requiring treatment within the past three months. * A respiratory condition that would be exacerbated by high intensity exercise including but not limited to: chronic obstructive pulmonary disorder, uncontrolled or poorly controlled asthma. * Uncontrolled high pressure at screening (>190/100 mmHg) * Cognitive impairment affecting ability to understand instructions as noted in patient's notes. * Currently engaging in another research trial for their MS or that may affect their physiological or cardiovascular outcomes * Weighing more than 110 kg (weight limit of ergometer) * Any pathology or medical intervention that would preclude high intensity exercise, maximal exertion testing or could attenuate the cardiovascular effect of exercise including but not limited to: unstable angina; diabetes; peripheral vascular disease or intermittent claudication; having a pace maker or medicine pump; surgical clips; having another neurological condition other than MS; and pregnancy. To be established from patient's notes and at screening session. * A serious cardiovascular event in the past year including but not limited to: transient ischaemic attack, cerebrovascular event and myocardial infarction. * Taking any of the following medication: beta blockers; vasodilators; ACE inhibitors; diuretics or any other medication that could cause exercise induced hypotension; hypoglycaemic insulin; metformin or other oral insulin medicine.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This is a pilot trial to explore the cardiovascular of eight weeks of twice weekly high intensity interval training in people with progressive multiple sclerosis. A control group of people with progressive multiple sclerosis will undergo continuous moderate intensity exercise, twice weekly for 8 weeks.
Loading reviews and guidelines…
History
Started
Jan 2017
Main results due
Sept 2017
Finished
Sept 2017