Light Therapy as Treatment for Fatigue in Multiple Sclerosis
Light Therapy as Treatment for Fatigue in Multiple Sclerosis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Light Therapy box
Results by group
Change in Average Fatigue Severity Scale (FSS) Score
4 weeks
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Light Therapy-Spectrum 1 | 45.824 score on a scale | 11.8 (Standard Deviation) | 17 |
| Light Therapy-Spectrum 2 | 46.714 score on a scale | 10.2 (Standard Deviation) | 14 |
Light Therapy-Spectrum 1
Light Therapy-Spectrum 2
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Light Therapy-Spectrum 1 | 17 | 0 (0.0%) | 0 |
| Light Therapy-Spectrum 2 | 14 | 0 (0.0%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Change in Average Fatigue Severity Scale (FSS) Score
4 weeks
Fatigue
Who could take part
Relapsing MS · 18 to 70
Show the full criteria
Inclusion criteria
* Relapsing remitting Multiple Sclerosis based on the McDonald Criteria (2010) * Over 18 years old * Presence of fatigue defined as FSS over 36
Exclusion criteria
* A change in an anti-depressant up to 4 weeks prior to study screening * A change in fatigue medication regime or MS disease modifying therapy up to 4 weeks prior to study screening * Shift work * Use of photosensitizing medication * Presence of eye trauma or acute optic neuritis within the preceding 3 months * History of traumatic brain injury * Probable (untreated) sleep apnea based on Berlin questionnaire * Significant anemia * History of mania * MS relapse in the preceding four weeks * Current pregnancy * Known light sensitivity * Other complicating illness preventing study completion.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This prospective study will randomize 1:1 people living with multiple sclerosis-associated fatigue to one of two spectra of light therapy. Each participant will be asked to use the light box twice daily at home or at the workplace at preset hours during the day for a total of four weeks. Participants will be asked to record their fatigue on standard measurement scales before, during, and after the use of the light therapy box. The investigators anticipate a reduction in self-reported fatigue following the use of the light box therapy of a particular spectrum of light among people living with multiple sclerosis.
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History
Started
Apr 2017
Main results due
Jun 2019
Finished
Nov 2019
Results posted
May 2020