Reducing Sedentary Behaviour: A Novel Opportunity for Managing Comorbidity in MS?

CompletedNot a drug-phase studyMS (type not specified)NCT03136744

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Sit Less with MS

What it measured

Main measures

  • Number of sedentary interruptions per day

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Physical function
  • Average sedentary time per day

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Physical function

Other measures (12)

  • Patient Determined Disease Steps (PDDS)

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Quality of life (reported by participants)
  • Fatigue Severity Scale (FSS)

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    FatigueQuality of life (reported by participants)
  • Modified Fatigue Impact Scale

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Fatigue
  • Symbol Digit Modality Test

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Thinking and memory
  • Hospital Anxiety and Depression Scale

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Mood and sleep
  • Short Form McGill Pain Questionnaire

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Pain
  • Pittsburgh Sleep Quality Questionnaire

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Mood and sleep
  • Godin-Shephard Leisure-Time Physical Activity Questionnaire

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Physical function
  • 6-minute Walk Test

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Walking and mobility
  • 10-meter Walk test

    Baseline (week 0), post-intervention (week 16), and follow-up (week 24)

    Walking and mobility

Who could take part

MS (type not specified) · 18 to 70 · EDSS 1 to 6.5

Show the full criteria

Inclusion criteria

* confirmed diagnosis of MS of at least one-year duration. * Expanded Disability Status Scale (EDSS) scores between 1 and 6.5. * stable in terms of disease modifying drugs and rehabilitation over the previous 6 months. * relapse free within the previous 3 months. * physically inactive, defined as insufficiently active by Godin-Shephard Leisure-Time Physical Activity Questionnaire. * able to walk with or without a walking aid for 10 meters.

Exclusion criteria

• other neurological problems besides MS or medically unstable to engage in the program.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Activity recommendations for the general population and those with multiple sclerosis (MS) focus on the promotion of activity that has a moderate intensity - in other words, activity intense enough to breathe heavily and sweat. Most adults do not achieve the recommended 150 minutes of moderate-intensity activity per week. Even fewer persons with MS meet the recommendations. Those with MS often have problems with walking and fatigue, thus it is not difficult to understand that moderate intensity activity is challenging. Our study will test the feasibility of a new approach focusing on activity over the whole day - promoting light activity such as standing or walking around the house while reducing prolonged sitting (sedentary behaviour). This approach is supported by research evidence showing that too much sedentary time, especially prolonged bouts of sitting, is associated with health risk factors such as obesity and cholesterol level. Recent work with persons with MS confirms that prolonged sitting is a problem for this population and emphasises the potential importance of this approach. This study tests the feasibility of an internet-based intervention designed to decrease sedentary behaviour and to increase upright time in people with MS.

Papers

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History

    1. Started

      Feb 2018

    2. Main results due

      Jun 2019

    3. Finished

      Dec 2019

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