Reducing Sedentary Behaviour: A Novel Opportunity for Managing Comorbi
Reducing Sedentary Behaviour: A Novel Opportunity for Managing Comorbidity in MS?
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Sit Less with MS
What it measured
Main measures
Number of sedentary interruptions per day
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Physical functionAverage sedentary time per day
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Physical function
Other measures (12)
Patient Determined Disease Steps (PDDS)
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Quality of life (reported by participants)Fatigue Severity Scale (FSS)
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
FatigueQuality of life (reported by participants)Modified Fatigue Impact Scale
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
FatigueSymbol Digit Modality Test
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Thinking and memoryHospital Anxiety and Depression Scale
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Mood and sleepShort Form McGill Pain Questionnaire
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
PainPittsburgh Sleep Quality Questionnaire
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Mood and sleepGodin-Shephard Leisure-Time Physical Activity Questionnaire
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Physical function6-minute Walk Test
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Walking and mobility10-meter Walk test
Baseline (week 0), post-intervention (week 16), and follow-up (week 24)
Walking and mobility
Who could take part
MS (type not specified) · 18 to 70 · EDSS 1 to 6.5
Show the full criteria
Inclusion criteria
* confirmed diagnosis of MS of at least one-year duration. * Expanded Disability Status Scale (EDSS) scores between 1 and 6.5. * stable in terms of disease modifying drugs and rehabilitation over the previous 6 months. * relapse free within the previous 3 months. * physically inactive, defined as insufficiently active by Godin-Shephard Leisure-Time Physical Activity Questionnaire. * able to walk with or without a walking aid for 10 meters.
Exclusion criteria
• other neurological problems besides MS or medically unstable to engage in the program.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Activity recommendations for the general population and those with multiple sclerosis (MS) focus on the promotion of activity that has a moderate intensity - in other words, activity intense enough to breathe heavily and sweat. Most adults do not achieve the recommended 150 minutes of moderate-intensity activity per week. Even fewer persons with MS meet the recommendations. Those with MS often have problems with walking and fatigue, thus it is not difficult to understand that moderate intensity activity is challenging. Our study will test the feasibility of a new approach focusing on activity over the whole day - promoting light activity such as standing or walking around the house while reducing prolonged sitting (sedentary behaviour). This approach is supported by research evidence showing that too much sedentary time, especially prolonged bouts of sitting, is associated with health risk factors such as obesity and cholesterol level. Recent work with persons with MS confirms that prolonged sitting is a problem for this population and emphasises the potential importance of this approach. This study tests the feasibility of an internet-based intervention designed to decrease sedentary behaviour and to increase upright time in people with MS.
Papers
Results
Mehrabani G, Aminian S, Norton S, Motl RW, Manns PJ. Preliminary efficacy of the "SitLess with MS" intervention for changing sedentary behaviour, symptoms, and physical performance in multiple sclerosis. Disabil Rehabil. 2022 Oct;44(21):6374-6381. doi: 10.1080/09638288.2021.1966520. Epub 2021 Aug 25.Results
Aminian S, Motl RW, Rowley J, Manns PJ. Management of multiple sclerosis symptoms through reductions in sedentary behaviour: protocol for a feasibility study. BMJ Open. 2019 Apr 1;9(4):e026622. doi: 10.1136/bmjopen-2018-026622.Background
Healy GN, Dunstan DW, Salmon J, Cerin E, Shaw JE, Zimmet PZ, Owen N. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008 Apr;31(4):661-6. doi: 10.2337/dc07-2046. Epub 2008 Feb 5.Background
Healy GN, Matthews CE, Dunstan DW, Winkler EA, Owen N. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur Heart J. 2011 Mar;32(5):590-7. doi: 10.1093/eurheartj/ehq451. Epub 2011 Jan 11.Background
Owen N, Healy GN, Matthews CE, Dunstan DW. Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev. 2010 Jul;38(3):105-13. doi: 10.1097/JES.0b013e3181e373a2.Background
van der Ploeg HP, Chey T, Korda RJ, Banks E, Bauman A. Sitting time and all-cause mortality risk in 222 497 Australian adults. Arch Intern Med. 2012 Mar 26;172(6):494-500. doi: 10.1001/archinternmed.2011.2174.
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History
Started
Feb 2018
Main results due
Jun 2019
Finished
Dec 2019