Strength Training to Improve Gait in People With Multiple Sclerosis
Targeted Strength Training to Improve Gait in People With Multiple Sclerosis: a Feasibility Study
What it found
We found no results in the registry or in papers.
This trial finished 8 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Strength exercise
What it measured
Main measures
Change in Muscle Strength
Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up)
Physical functionChange in Timed 25 Foot Walk (T25FW)
Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up)
Disability progressionWalking and mobility
Other measures (4)
Change in 6-Minute Walk Test
Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up)
Walking and mobilityChange in Dynamic Gait Index
Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up)
Walking and mobilityChange in Multiple Sclerosis Walking Scale-12
Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up)
Walking and mobilityChange in Patient Specific Functional Scale
Week 0 (Baseline 1); Week 10 (Follow-Up)
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
1. People with MS, 2. Age 18-65, 3. A confirmed diagnosis of MS, and 4. Are ambulatory for 100m without an assistive device (EDDS 0-5.5), and 5. Have a gait speed measured by time to walk the 25-foot walk test of at least five seconds.
Exclusion criteria
1. Subjects are not ambulatory, 2. Subjects rely on a wheelchair, 3. Subjects cannot ambulate 100m (EDDS 6 or greater) without use of assistive devices, braces, or orthotics, 4. Walk the T25FW in less than five seconds, 5. Have lower extremity spasticity of 2 or greater on the Modified Ashworth Scale (MAS), 6. Have pain or other conditions that limit ambulation or ability to test muscle strength, 7. Cannot give consent, 8. Cannot follow simple directions, 9. Have had an exacerbation in the past month, 10. Have had changes to their drug therapy in the last month, 11. Have other neurologic diagnoses, or 12. Are currently undergoing physical therapy for strength training.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study will pilot a strengthening intervention targeted to muscles found to be important to gait in people with multiple sclerosis (MS). Previous studies that have tried to strengthen leg and trunk muscles in people with MS have failed to improve walking ability consistently. The investigators think that is because strengthening exercises were not targeted to the correct muscle groups. For this study the investigators propose targeting muscle groups that they have found to be strong contributors to walking in a prior study. This is the first study to target these muscles, so the investigators propose doing a small trial to first evaluate the feasibility of the strength program and the outcomes. The investigators will measure strength and walking measures twice before and once after an 8-week strengthening intervention in a single group of 10 people with MS who are able to walk independently. The results of this study will help inform future, larger trials that could change the way strength training is conducted in people with MS.
Papers
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History
Started
May 2017
Main results due
Nov 2017
Finished
Nov 2017