Behavior and Activity Monitoring in MS
Behavior and Activity Monitoring in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Step Tracking
Compared with
- Water Tracking
What it measured
Main measures
Change in Cognitive Performance on a Latent Measure of Working Memory/Processing Speed
Baseline, 3 months, and 6 months
Thinking and memory
Other measures (8)
Changes in the Functional Architecture of the MS Brain during Working Memory
Baseline and 6 months
MRI lesionsThinking and memoryPhysical functionNerve conduction testsChanges in the Functional Architecture of the MS Brain during Processing Speed
Baseline and 6 months
MRI lesionsThinking and memoryPhysical functionNerve conduction testsChanges on a Self-Report Measure of Depression
Baseline, 3 months, and 6 months
Mood and sleepChanges on a Self-Report Measure of Anxiety
Baseline, 3 months and 6 months
Mood and sleepChanges on a Self-Report Measure of Perceived Stress
Baseline, 3 months and 6 months
Changes on a Self-Report Measure of Quality of Life
Baseline, 3 months and 6 months
Quality of life (reported by participants)Changes on a Self-Report Measure of Sleep Quality
Baseline, 3 months and 6 months
Mood and sleepChanges on a Self-Report Measure of Fatigue
Baseline, 3 months and 6 months
Fatigue
Who could take part
Relapsing MS · 30 to 59
Show the full criteria
Inclusion criteria
* Clinically definite diagnosis of Relapsing-Remitting Multiple Sclerosis * Score higher than 23 on the Mini-Mental Status Examination (MMSE) * Expanded Disability Status Scale (EDSS) under 5.5 * Right-handed
Exclusion criteria
* Clinically isolated syndrome or progressive MS subtype * Presence of any other neurological disorders * Presence of psychiatric disorder diagnosed by a licensed mental health provider in the last two years * Clinically definite relapse or use of high dose corticosteroids within the last 30 days * Recreational drug use in the last 6 months * Without access to a smart phone or no access to the internet * Current use of accelerometer, pedometer, and/or physical activity monitoring equipment * Presence of ferromagnetic implanted devices or self-reported claustrophobia
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The investigators propose to conduct a randomized 6-month intervention study comparing cognitive functioning in individuals with relapsing-remitting multiple sclerosis assigned to either a physical activity or an active water-intake control group. Individuals will complete pre-, mid- and post-assessments of cognitive, physical, and behavioral functioning.
Papers
Results
Accelerometry measures of physical activity and sedentary behavior: Associations with cognitive functioning in MS.Mult Scler Relat Disord · 2023
Results
Employing Connectome-Based Models to Predict Working Memory in Multiple Sclerosis.Brain Connect · 2022
Results
Phansikar M, Duraney EJ, Manglani HR, Shankar A, Roberts C, Andridge R, Nicholas JA, Petosa R, Prakash RS. TRACking health behavior in people with multiple sclerosis: Effects of a randomized trial on physical activity and working memory. Rehabil Psychol. 2025 Aug;70(3):227-239. doi: 10.1037/rep0000578. Epub 2024 Aug 29.
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History
Started
Nov 2017
Main results due
Jun 2021
Finished
Jun 2021