Comparative Effectiveness Study Telerehab Versus Conventional
Comparative Effectiveness Study of an Exercise Intervention Delivered Via Telerehabilitation and Conventional Mode of Delivery
We could not find results for this trial
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Exercise program for people with MS
Results by group
Timed 25 Foot Walk Test (T25FWT)
Change from baseline T25FWT at 16-weeks
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Facility-based Rehabilitation | 2.88 feet per second | 0.85 (Standard Deviation) | 198 |
| Telerehabilitation | 2.62 feet per second | 0.94 (Standard Deviation) | 181 |
| Facility-based Rehabilitation | 3.41 feet per second | 1.12 (Standard Deviation) | 198 |
| Telerehabilitation | 3.26 feet per second | 1.08 (Standard Deviation) | 181 |
Facility-based Rehabilitation
Telerehabilitation
Facility-based Rehabilitation
Telerehabilitation
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Facility-based Rehabilitation | 198 | 8 (4.0%) | 0 |
| Telerehabilitation | 181 | 2 (1.1%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Timed 25 Foot Walk Test (T25FWT)
Change from baseline T25FWT at 16-weeks
Disability progressionWalking and mobility
Other measures (8)
Six Minute Walk Test (6MWT)
Change from baseline at 16 weeks
Walking and mobilityPhysical functionMultiple Sclerosis Walking Scale (MSWS)-12 Questionnaire
Change from baseline at 16 weeks
Walking and mobilityGodin Leisure-Time Physical Activity (LTPA) Questionnaire
Change from baseline at 16 weeks
Walking and mobilityPhysical functionQuality of Life in Neurological Disorders (Neuro-QOL) Survey
Change from baseline at 16 weeks.
Thinking and memoryFatigueArm and hand functionMood and sleepQuality of life (reported by participants)Multiple Sclerosis Impact Scale (MSIS)-29
Change from baseline at 16 weeks.
Quality of life (reported by participants)Modified Fatigue Impact Scale (MFIS)
Change from baseline at 16 weeks
Thinking and memoryFatigueExpanded Disability Status Scale (EDSS)
Change from baseline at 16 weeks
Disability progressionPatient Determined Disease Steps (PDDS)
Change from baseline at 16 weeks
Walking and mobilityQuality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Mild to moderate MS * Has limitations in walking but can walk 25 feet * Does not participate in a rigorous exercise program * Can travel to trial site for assessments and training
Exclusion criteria
* Relapse in the past 30 days * Other neurological or musculoskeletal disorders
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study aims to compare the effectiveness of an exercise program delivered in a conventional facility-based format versus a telerehabilitation format, which takes place in the home. Exercise can improve mobility and perhaps decrease the rate and extent of disability in people with MS. Evidence shows that traditional, facility-based exercise training may help people with MS consistently participate in exercise or to exercise at a higher, more intense level. Despite this evidence, lack of access to facility-based exercise programs may make it difficult for people with MS to engage in exercise.Telerehabilitation (telerehab) has great potential to overcome challenges associated with facility-based programs. Telerehab can include videoconferencing, remote monitoring of signs and activity, and dissemination of specialized and individualized information via electronic mechanisms, such as smartphones and computers. Both facility-based and telerehab exercise training have yielded positive results in people with MS, but have not been compared head-to-head. The current study will fill this gap in the evidence base and compare the outcomes of delivering the same exercise interventions in a facility or in the home/community using a telerehab approach. The interventions are designed to be identical in content, with the only difference being the mode of training delivery.
Papers
Results
Middle-range scores from the patient determined disease steps scale reflect varying levels of walking dysfunction in multiple sclerosis.BMC Neurol · 2024
Results
Feasibility, acceptability, and initial efficacy of a wheelchair exercise training program in persons with multiple sclerosis: study protocol for a parallel group randomized controlled trial.Disabil Rehabil Assist Technol · 2024
Results
Motl RW, Backus D, Hebert JR, Ng AV, McCully KK, Neal WN, Schmidt H, McBurney R, Plummer P, Bethoux F, Lowman J, Cutter G. Walking performance is worse in black than white people with multiple sclerosis. Mult Scler Relat Disord. 2025 Mar;95:106343. doi: 10.1016/j.msard.2025.106343. Epub 2025 Feb 18.Background
Motl RW, Backus D, Neal WN, Cutter G, Palmer L, McBurney R, Schmidt H, Bethoux F, Hebert J, Ng A, McCully KK, Plummer P. Rationale and design of the STEP for MS Trial: Comparative effectiveness of Supervised versus Telerehabilitation Exercise Programs for Multiple Sclerosis. Contemp Clin Trials. 2019 Jun;81:110-122. doi: 10.1016/j.cct.2019.04.013. Epub 2019 Apr 22.Background
Neal WN, Moldavskiy M, Truax B, Ithurburn A, Ware M, Hebert JR, Opielinski L, Penko AL, Kern K, Palmer L, Backus D, Motl RW. Intervention fidelity and adaptation in a multi-site exercise training intervention for adults with multiple sclerosis. Contemp Clin Trials. 2023 Oct;133:107320. doi: 10.1016/j.cct.2023.107320. Epub 2023 Aug 24.Background
Palmer LC, Neal WN, Motl RW, Backus D. The Impact of COVID-19 Lockdown Restrictions on Exercise Behavior Among People With Multiple Sclerosis Enrolled in an Exercise Trial: Qualitative Interview Study. JMIR Rehabil Assist Technol. 2022 Nov 22;9(4):e42157. doi: 10.2196/42157.Background
Motl RW, Plummer P, Backus D, Hebert JR, Neal WN, Ng A, Lowman J, Bethoux F, Schmidt H, McBurney R, McCully KK, Cutter G. Validation of scores from a telephone administered multiple sclerosis walking scale-12 in persons with multiple sclerosis. Mult Scler Relat Disord. 2024 Aug;88:105715. doi: 10.1016/j.msard.2024.105715. Epub 2024 Jun 9.
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History
Started
Jul 2018
Main results due
Sept 2023
Finished
Sept 2023
Results posted
Dec 2024