Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
The Impact of Motor Rehabilitation on the Dynamic Properties of the Brain: Towards the Individual Tailoring of Therapeutic Interventions in Multiple Sclerosis Patients
What it found
We found no results in the registry or in papers.
This trial finished 11 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Voluntary-based upper limb motor rehabilitation
Compared with
- Passive upper limb mobilization
What it measured
Main measures
Change in the time to perform the Nine Hole Peg Test (NHPT)
Baseline and 8 weeks
Arm and hand function
Other measures (3)
Score obtained at the Action Research Arm Test (ARAT)
Baseline and 8 weeks
Arm and hand functionGrip and pinch strength
Baseline and 8 weeks
Arm and hand functionPhysical functionBrain activity (blood-oxygenation-level dependent signal)
Baseline and 8 weeks
MRI lesions
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Multiple sclerosis diagnosis according to McDonald criteria * right handedness as assessed by the Edinburgh Handedness Inventory * absence of relapses in the last three months * mild or moderate sensorimotor impairment in one or both upper limbs as evaluated by means of the Medical Research Council scale (grade 3-4)
Exclusion criteria
* steroid-use or a worsening of the Expanded Disability Status Scale (EDSS) score in the last three months * psychiatric disorders * severe cognitive impairment * magnetic resonance imaging contraindications
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Motor learning can induce significant changes in the human brain through neural plasticity processes, which play a crucial role in the brain functional reorganization in response to external stimuli and/or to pathological conditions. For example, people with multiple sclerosis present motor deficits often associated with cerebral activity alteration. However, whether these brain activation changes contribute to or protect against motor performance deficits still needs to be determined. Moreover, rehabilitation protocols could be designed to obtain efficient brain adaptation to preserve patients' outcome, but consistent data on the real efficacy of rehabilitative procedures are lacking, in particular concerning the rehabilitation effect on brain networks. Therefore, this project focuses on the degree to which imaging measures of functional brain activity can give new hints on the effects of motor rehabilitative protocols in multiple sclerosis patients' performance. Particularly, the investigator's aim is to investigate the effects of upper limb rehabilitation, focused on hand motor function, and the correlation between motor performance and functional magnetic resonance data.
Papers
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History
Started
Sept 2013
Main results due
Dec 2014
Finished
Mar 2015