Exercise and Brain Health in MS
Exercise and Brain Health in Multiple Sclerosis: A Pilot Study
What it found
We found no results in the registry or in papers.
This trial finished 7 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Twice-weekly exercise
What it measured
Main measures
Change in Perceived Fatigue
Outcome will be measured at Baseline, 12 weeks and 24 weeks.
FatigueChange in Inflammatory Markers
Outcome will be measured at Baseline, 12 weeks and 24 weeks.
Immune responseChange in Depression
Outcome will be measured at Baseline, 12 weeks and 24 weeks.
Mood and sleepChange in Cognition
Outcome will be measured at Baseline, 12 weeks and 24 weeks.
Thinking and memory
Other measures (3)
Change in Aerobic Capacity
Outcomes will be measured at Baseline, 12 weeks and 24 weeks.
Physical functionChange in Muscle Strength
Outcomes will be measured at Baseline, 12 weeks and 24 weeks.
Physical functionChange in Perceived Quality of Life (QOL)
Outcomes will be measured at Baseline, 12 weeks and 24 weeks.
Quality of life (reported by participants)
Who could take part
Relapsing MS · 18 to 65 · EDSS 2 to 5
Show the full criteria
Inclusion criteria
* Diagnosis of Relapsing-Remitting MS (RRMS) with mild-moderate disability (EDSS 2-5) * Aged 18-60 * Score of ≥ 10 on MFIS-5* * Medical clearance to participate in physical activity * The MFIS-5 is an abbreviated version of the 21-item MFIS, consisting of 5 of the 21 items of the MFIS that most strongly correlate with the total MFIS score. A score ≥ 10 on the MFIS-5 is considered to indicate "high-level" of fatigue
Exclusion criteria
* Current participation in regular physical activity (at least twice-weekly) * Other serious medical condition that might impair ability to participate in strength or aerobic exercise
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Physical activity is now recognized as a therapy for Multiple Sclerosis (MS) that not only improves physical fitness and functional mobility, but there is some evidence that it may also positively influence the more invisible symptoms of the disease that represent "brain health" - fatigue, depression and cognitive impairment. One important feature of physical activity is that it reduces inflammation throughout the body and the brain. The goal of this research is to determine whether people with MS feel less fatigue, depression and cognitive impairment after a program of exercise because there is a decrease in the state of inflammation in the brain.
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History
Started
Aug 2018
Main results due
Jun 2019
Finished
Sept 2019