Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Lon
Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Longitudinal 7T Magnetic Resonance Imaging Study
We could not find results for this trial
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- MRI 7T
What it measured
Main measures
number of cortical lesions
2 hours
MRI lesions
Who could take part
MS (type not specified) · 18 to 50
Show the full criteria
Inclusion criteria
* First presumed inflammatory demyelinating event in the central nervous system involving either the optic nerve, the spinal cord, a brain hemisphere, or the brainstem without spatial and time dissemination criteria * Oligoclonal bands on CSF analysis * Age between 18 and 45 * No previous history of neurological symptoms suggestive of demyelination * No steroids in the month before MRI * First MRI within six months after the first clinical episode
Exclusion criteria
* Possible alternative diagnoses * Previous history of neurological or psychiatric disease * Previous administration of immunosuppressive drugs * Pregnancy * Patient unable to give his consent for the study or patient under tutorship
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The present study is an opportunity to assess grey matter damage at the earliest phase of Multiple Sclerosis (MS) allowing to a better understanding of its origins and its impact and disease severity. This study is a preliminary longitudinal study to precisely depict the kinetic of grey matter damage and the links with disease aggravation. Thirty MS patients without time and spatial dissemination criteria (only one symptomatic MRI lesion detected) but with oligoclonal bands detected on cerebro spinal fluid analysis will be included for a monocentric transversal MRI study at 7T to assess grey matter injury. Clinical and neuropsychological assessments will be performed in the population the same day of a multi-parametric MRI. A longitudinal clinical and MRI follow up will be performed during 2 years.
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History
- Status changed from Running, not recruiting to Status unknown
- Result signal changed from Ongoing to Status unknown
Started
Dec 2018
Main results due
May 2022
Finished
Nov 2026