Computerized Cognitive Training in MS
Computerized Cognitive Training for Patients With Cognitive Deficits Due to Multiple Sclerosis: a Pilot Study
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 20 months ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Computerized gaming rehabilitation Program 1
Placebo
- Computerized gaming rehabilitation Program 2
What it measured
Main measures
Change in processing speed after 4 weeks of treatment with computerized gaming rehabilitation paired with physical activity 'Program 1', vs. 'Program 2'.
4 weeks
Thinking and memoryPhysical function
Other measures (4)
Change in attention after 4 weeks of treatment with computerized gaming rehabilitation paired with physical activity 'Program 1', vs. 'Program 2'.
4 weeks
Thinking and memoryPhysical functionChange in visual working memory after 4 weeks of computerized gaming rehabilitation paired with physical activity 'Program 1', vs. 'Program 2'.
4 weeks
Thinking and memoryPhysical functionChange in multitasking performance following 4 weeks of computerized paired with physical activity 'Program 1', vs. 'Program 2'.
4 weeks
Physical functionChange in working memory following 4 weeks of computerized paired with physical activity 'Program 1', vs. 'Program 2'.
4 weeks
Thinking and memoryPhysical function
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
* Age between 18 and 60 years * Presence of subjective cognitive complain from patient * Objective general cognitive impairment: paper-and-pencil Symbol Digit Modalities Test (SDMT) z-score \< -0.5 at screening
Exclusion criteria
* Falls in the past 12 weeks as evaluated in the enrollment interview [Hopkins Falls Grading Scale (Grade >1)] * Strong risk of falling, assessed using the miniBEST (score\< 16) * Psychiatric co-morbidity or anti-depressive or anxiolytic medication that has been changed over the 6 months preceding consideration for study enrollment * Colorblindness * Presence of clinically and/or radiologically confirmed relapses or disease progression in the past 12 weeks. * Visual, mental, motor or brainstem Functional Systems Score (FSS) on the Expanded Disability Status Scale (EDSS) superior to 2.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in moderate physical activity. WHY: The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for patients with MS. WHAT: Complete a set of tests (physical and cognitive) at baseline, wear a Fitbit Flex device at home for the duration of the study, 3 supervised sessions for 4 weeks at UCSF, one visit for physical and cognitive tests at one week after the final supervised session, and one final visit 6 months after the final supervised session. WHERE: 20 participants at the UCSF Weill Institute for Neurosciences (675 Nelson Rising Lane, San Francisco, CA); 20 participants at Lausanne University Hospital (Rue du Bugnon 46, 1005 Lausanne, Switzerland)
Papers
Background
Braverman ER, Chen TJ, Schoolfield J, Martinez-Pons M, Arcuri V, Varshavskiy M, Gordon CA, Mengucci J, Blum SH, Meshkin B, Downs BW, Blum K. Delayed P300 latency correlates with abnormal Test of Variables of Attention (TOVA) in adults and predicts early cognitive decline in a clinical setting. Adv Ther. 2006 Jul-Aug;23(4):582-600. doi: 10.1007/BF02850047.Background
Forbes GB. Clinical utility of the Test of Variables of Attention (TOVA) in the diagnosis of attention-deficit/hyperactivity disorder. J Clin Psychol. 1998 Jun;54(4):461-76. doi: 10.1002/(sici)1097-4679(199806)54:43.0.co;2-q.Background
Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, Gazzaley A. Video game training enhances cognitive control in older adults. Nature. 2013 Sep 5;501(7465):97-101. doi: 10.1038/nature12486.Background
Vogel EK, McCollough AW, Machizawa MG. Neural measures reveal individual differences in controlling access to working memory. Nature. 2005 Nov 24;438(7067):500-3. doi: 10.1038/nature04171.
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History
Started
Apr 2019
Main results due
Feb 2025
Finished
Feb 2025