B Cell Differentiation in MS
Analysis of B Cell Differentiation in Multiple Sclerosis
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 3 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Biological Samples
What it measured
Main measures
Plasmablasts frequency
At Day 6 after differentiation of B cells
Immune response
Who could take part
Early (CIS/RIS) · 18 and over
Show the full criteria
Inclusion criteria
Regarding MS patients (remitting or progressive untreated): * Adult (age greater than or equal to 18 years) of both sexes; * MS fulfilling the criteria of McDonald 2017; * Remittent or progressive form; * No immunomodulatory or immunosuppressive therapy for at least 3 months; * Free, informed and written consent signed by the patient. Regarding Clinically Isolated Syndrome: * Adult (age greater than or equal to 18 years) of both sexes; * Clinically isolated syndrome suggestive of MS (at least two typical lesions in two different locations); * Patient receiving a Lumbar Puncture (PL) for diagnostic purposes; * No immunomodulatory or immunosuppressive therapy for at least 3 months; * Free, informed and written consent signed by the patient. Regarding non-MS patients with neurological inflammatory disease: * Adult (age greater than or equal to 18 years) of both sexes; * Patient with non-MS neurological inflammatory disease (examples: meningitis, neurolupus, neurosarcoidosis...); * Patients with PL for diagnostic or surveillance purposes; * No immunomodulatory or immunosuppressive therapy for at least 3 months; * Free, informed and written consent signed by the patient. Regarding healthy volunteers: * Adult (age greater than or equal to 18 years) of both sexes; * Free, informed and written consent signed by the volunteer.
Exclusion criteria
Regarding all patients: * Pregnancy; * Breastfeeding; * Treatment with corticotherapy in the last month; * Patient not affiliated to social security; * Persons major subject to legal protection (safeguard of justice, guardianship, tutorship), persons deprived of their liberty. Regarding healthy volunteers: * Pregnancy; * Breastfeeding; * Not affiliated to social security; * Persons major subject to legal protection (safeguard of justice, guardianship, tutorship), persons deprived of their liberty.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Interventional study with minimal risks and constraints, prospective, monocentric.
Papers
Loading reviews and guidelines…
Linked trials
Referred to by
Investigation of Novel Immunological Biomarkers by Mass Cytometry in PCompleted
Referred to by
MUltiple Sclerosis : T Cell / B Cell ExplorationCompleted
Links found where a registry record names another trial's registry number.
History
Started
Feb 2019
Main results due
May 2023
Finished
May 2023