Isokinetic Exercises in Patients With Multiple Sclerosis
The Effects of Isokinetic Exercises on Muscle Strength, Joint Position Sense, and Kinesiophobia in Patients With Multiple Sclerosis: a Randomized Controlled Trial
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- exercises
Results by group
Isokinetic Muscle Strength Test of the More and Less Affected Knees
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Isokinetic Exercise Baseline | 110.48 Newton/meter | 37.2 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 141.05 Newton/meter | 31.59 (Standard Deviation) | 19 |
| Home Exercise Baseline | 123.02 Newton/meter | 53.8 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 127.83 Newton/meter | 54.35 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 69.25 Newton/meter | 24.28 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 85.87 Newton/meter | 21 (Standard Deviation) | 19 |
| Home Exercise Baseline | 72.85 Newton/meter | 29.02 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 78.40 Newton/meter | 31.21 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 0.63 Newton/meter | 0.14 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 0.61 Newton/meter | 0.12 (Standard Deviation) | 19 |
| Home Exercise Baseline | 0.61 Newton/meter | 0.14 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 0.62 Newton/meter | 0.12 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 59.87 Newton/meter | 24.51 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 82.87 Newton/meter | 23.11 (Standard Deviation) | 19 |
| Home Exercise Baseline | 71.06 Newton/meter | 32.01 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 76.54 Newton/meter | 28.73 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 46.74 Newton/meter | 17.76 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 56.85 Newton/meter | 19.74 (Standard Deviation) | 19 |
| Home Exercise Baseline | 53.73 Newton/meter | 22.55 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 56.76 Newton/meter | 21.21 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 0.80 Newton/meter | 0.19 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 0.69 Newton/meter | 0.19 (Standard Deviation) | 19 |
| Home Exercise Baseline | 0.76 Newton/meter | 0.22 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 0.74 Newton/meter | 0.18 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 82.46 Newton/meter | 43.96 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 118.50 Newton/meter | 45.52 (Standard Deviation) | 19 |
| Home Exercise Baseline | 100.16 Newton/meter | 47.85 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 108.06 Newton/meter | 48.83 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 58.87 Newton/meter | 33.6 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 77.70 Newton/meter | 29.27 (Standard Deviation) | 19 |
| Home Exercise Baseline | 67.00 Newton/meter | 30.87 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 72.80 Newton/meter | 31.55 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 0.77 Newton/meter | 0.27 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 0.65 Newton/meter | 0.12 (Standard Deviation) | 19 |
| Home Exercise Baseline | 0.71 Newton/meter | 0.22 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 0.71 Newton/meter | 0.22 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 52.42 Newton/meter | 25.08 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 73.62 Newton/meter | 23.53 (Standard Deviation) | 19 |
| Home Exercise Baseline | 57.18 Newton/meter | 30.59 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 62.03 Newton/meter | 29.38 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 42.25 Newton/meter | 25.19 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 51.38 Newton/meter | 23.24 (Standard Deviation) | 19 |
| Home Exercise Baseline | 46.19 Newton/meter | 22.2 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 48.08 Newton/meter | 23.38 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 0.92 Newton/meter | 0.58 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 0.66 Newton/meter | 0.19 (Standard Deviation) | 19 |
| Home Exercise Baseline | 0.94 Newton/meter | 0.58 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 0.85 Newton/meter | 0.48 (Standard Deviation) | 21 |
Joint Position Sense of the More and Less Affected Knees
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Isokinetic Exercise Baseline | 5.56 degree | 2.78 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 4.39 degree | 2.32 (Standard Deviation) | 19 |
| Home Exercise Baseline | 5.70 degree | 3.19 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 5.03 degree | 2.65 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 4.94 degree | 3.06 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 4.38 degree | 1.94 (Standard Deviation) | 19 |
| Home Exercise Baseline | 5.76 degree | 5.35 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 4.99 degree | 3.59 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 6.26 degree | 4.7 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 3.87 degree | 4.28 (Standard Deviation) | 19 |
| Home Exercise Baseline | 5.93 degree | 5.26 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 5.32 degree | 4.07 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 4.61 degree | 3.79 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 0.74 degree | 4.04 (Standard Deviation) | 19 |
| Home Exercise Baseline | 4.96 degree | 4.05 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 5.27 degree | 3.82 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 6.41 degree | 3.61 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 5.86 degree | 3.95 (Standard Deviation) | 19 |
| Home Exercise Baseline | 6.23 degree | 4.36 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 4.94 degree | 3.04 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 4.73 degree | 3.81 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 4.21 degree | 2.95 (Standard Deviation) | 19 |
| Home Exercise Baseline | 5.80 degree | 5 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 5.46 degree | 4.62 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 3.40 degree | 3.08 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 3.39 degree | 3 (Standard Deviation) | 19 |
| Home Exercise Baseline | 4.55 degree | 4.78 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 3.76 degree | 4.73 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 6.02 degree | 4.99 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 4.17 degree | 2.52 (Standard Deviation) | 19 |
| Home Exercise Baseline | 4.18 degree | 6.67 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 3.47 degree | 3.92 (Standard Deviation) | 21 |
Tampa Scale of Kinesiophobia
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Isokinetic Exercise Baseline | 42.42 score on a scale | 5.48 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 40.57 score on a scale | 7.25 (Standard Deviation) | 19 |
| Home Exercise Baseline | 40.33 score on a scale | 6.37 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 40.33 score on a scale | 7.72 (Standard Deviation) | 21 |
Isokinetic Exercise Baseline
Isokinetic Exercise After Treatment
Home Exercise Baseline
Home Exercise After Treatment
Multiple Sclerosis Quality of Life-54 Total Score, Physical and Emotional Composite Scores, and Pain Subscale Score
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Isokinetic Exercise Baseline | 52.20 score on a scale | 17.98 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 57.00 score on a scale | 18.95 (Standard Deviation) | 19 |
| Home Exercise Baseline | 61.38 score on a scale | 18.54 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 59.39 score on a scale | 20.93 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 50.79 score on a scale | 17.02 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 54.69 score on a scale | 18.31 (Standard Deviation) | 19 |
| Home Exercise Baseline | 58.64 score on a scale | 19.81 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 56.69 score on a scale | 22.1 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 53.59 score on a scale | 20.71 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 59.33 score on a scale | 21.81 (Standard Deviation) | 19 |
| Home Exercise Baseline | 64.11 score on a scale | 20.41 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 62.07 score on a scale | 22.78 (Standard Deviation) | 21 |
| Isokinetic Exercise Baseline | 54.52 score on a scale | 26.9 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 58.57 score on a scale | 30.1 (Standard Deviation) | 19 |
| Home Exercise Baseline | 71.74 score on a scale | 28.52 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 67.83 score on a scale | 29.94 (Standard Deviation) | 21 |
Visual Analog Scale
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Isokinetic Exercise Baseline | 40.78 score on a scale | 34.16 (Standard Deviation) | 19 |
| Isokinetic Exercise After Treatment | 36.68 score on a scale | 36.66 (Standard Deviation) | 19 |
| Home Exercise Baseline | 41.66 score on a scale | 31.11 (Standard Deviation) | 21 |
| Home Exercise After Treatment | 42.14 score on a scale | 29.13 (Standard Deviation) | 21 |
Isokinetic Exercise Baseline
Isokinetic Exercise After Treatment
Home Exercise Baseline
Home Exercise After Treatment
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Isokinetic Exercise | 0 | 0 | 0 |
| Home Exercise | 0 | 0 | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Isokinetic Muscle Strength Test of the More and Less Affected Knees
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
Physical functionJoint Position Sense of the More and Less Affected Knees
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
Physical functionTampa Scale of Kinesiophobia
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
Physical functionMultiple Sclerosis Quality of Life-54 Total Score, Physical and Emotional Composite Scores, and Pain Subscale Score
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
Thinking and memoryFatigueBladder, bowel and sexual functionPainQuality of life (reported by participants)Visual Analog Scale
At baseline (10 minutes before the start of the treatment) and 8 weeks after start of the treatment
Pain
Who could take part
Relapsing and progressive · 18 to 65
Show the full criteria
Inclusion criteria
* definite relapsing remitting MS and secondary progressive MS diagnosis * mild and moderate MS determined by Kurtzke Expanded Disability Status Scale (EDSS) scores below 6.5 * a disease duration of more than one year.
Exclusion criteria
* having an acute exacerbation within the last three months * intravenous pulse steroid therapy in the last four weeks * grade 3-4 spasticity according to the Modified Ashworth Scale * severe vision impairment * severe fatigue and depression * past knee surgery * other neurologic diseases * systemic diseases * pregnancy * having received an exercise program within the last four weeks.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The investigators evaluated the effects of isokinetic muscle strengthening exercises of the quadriceps and hamstring on muscle strength, joint position sense, pain, kinesiophobia and quality of life in patients with multiple sclerosis.
Papers
Results
Selcuk MA, Cakit BD, Ergun U. Effects of isokinetic exercises on balance, proprioception, quality of life, and kinesiophobia in multiple sclerosis. Neurodegener Dis Manag. 2026 Apr;16(2):163-172. doi: 10.1080/17582024.2025.2552599. Epub 2025 Sep 2.Background
Yahia A, Ghroubi S, Mhiri C, Elleuch MH. Relationship between muscular strength, gait and postural parameters in multiple sclerosis. Ann Phys Rehabil Med. 2011 May;54(3):144-55. doi: 10.1016/j.rehab.2011.02.004. Epub 2011 Mar 9. English, French.Background
Robineau S, Nicolas B, Gallien P, Petrilli S, Durufle A, Edan G, Rochcongar P. [Eccentric isokinetic strengthening in hamstrings of patients with multiple sclerosis]. Ann Readapt Med Phys. 2005 Feb;48(1):29-33. doi: 10.1016/j.annrmp.2004.04.005. French.
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History
Started
Jul 2015
Main results due
Jul 2016
Finished
Jul 2016
Results posted
Jul 2019