MBCT and CBT for Chronic Pain in Multiple Sclerosis
Mindfulness-based Cognitive Therapy and Cognitive Behavioral Therapy for Chronic Pain in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- MBCT
- CBT
What it measured
Main measures
Change in average pain intensity
Baseline to 10 weeks (posttreatment; primary endpoint)
Pain
Other measures (9)
Pain interference
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
PainAverage pain intensity - maintenance
36 weeks (6-month follow up)
PainDepressive symptom severity
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
Mood and sleepPatient ratings of global improvement & satisfaction
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
Quality of life (reported by participants)Fatigue severity
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
FatigueSleep disturbance
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
Mood and sleepSelf-efficacy
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
PainPhysical Function
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
Global Quality of LIfe
baseline (week 0), 10 weeks (posttreatment), and 36 weeks (6-month follow up)
Quality of life (reported by participants)
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
Inclusion criteria are: 1. 18 years of age or older; 2. a diagnosis of clinically definite MS confirmed by participant's provider; 3. the presence of chronic pain, defined as average pain intensity in the past week of at least moderate severity (defined as a ≥3 on the 0-10 numerical rating scale) and pain of at least three months duration, with pain reportedly present > half the days in the past three months; 4. reads and speaks English; 5. has access and is able to communicate over the telephone; and 6. has a computer or digital device with video capabilities (any operating system) and internet access. Exclusion criteria are: 1. severe cognitive impairment; 2. currently in psychotherapy for pain > once a month; and 3. previously participated in a pain study that used CBT or MBCT.
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Chronic pain is one of the most prevalent, disabling and persistent symptoms affecting people with multiple sclerosis (MS). Different nonpharmacological treatments are known to be beneficial for managing pain, including cognitive behavioral therapy and mindfulness based cognitive therapy. This study compares these two non-pharmacological approaches to pain management in people with Multiple Sclerosis. The purpose of this study is to see if these treatments can help decrease pain and other outcomes (e.g., sleep, fatigue) in persons with Multiple Sclerosis. The study will determine who benefits from these treatments and if these treatments can be given effectively by videoconference.
Papers
Results
Mindfulness-based cognitive therapy and cognitive behavioral therapy for chronic pain in multiple sclerosis: a randomized controlled trial protocol.Trials · 2019
Background
Bogosian A, Chadwick P, Windgassen S, Norton S, McCrone P, Mosweu I, Silber E, Moss-Morris R. Distress improves after mindfulness training for progressive MS: A pilot randomised trial. Mult Scler. 2015 Aug;21(9):1184-94. doi: 10.1177/1352458515576261. Epub 2015 Mar 12.Background
Harris MA, Freeman KA, Duke DC. Seeing Is Believing: Using Skype to Improve Diabetes Outcomes in Youth. Diabetes Care. 2015 Aug;38(8):1427-34. doi: 10.2337/dc14-2469. Epub 2015 Jun 1.Background
Lion KC, Brown JC, Ebel BE, Klein EJ, Strelitz B, Gutman CK, Hencz P, Fernandez J, Mangione-Smith R. Effect of Telephone vs Video Interpretation on Parent Comprehension, Communication, and Utilization in the Pediatric Emergency Department: A Randomized Clinical Trial. JAMA Pediatr. 2015 Dec;169(12):1117-25. doi: 10.1001/jamapediatrics.2015.2630.Background
Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT. Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain. 2013 May;154(5):632-642. doi: 10.1016/j.pain.2012.12.002. Epub 2012 Dec 14.Background
Ehde DM, Dillworth TM, Turner JA. Cognitive-behavioral therapy for individuals with chronic pain: efficacy, innovations, and directions for research. Am Psychol. 2014 Feb-Mar;69(2):153-66. doi: 10.1037/a0035747.Background
Fedoroff IC, Blackwell E, Speed B. Evaluation of group and individual change in a multidisciplinary pain management program. Clin J Pain. 2014 May;30(5):399-408. doi: 10.1097/AJP.0b013e31829ea1f7.Background
Turner JA, Turk DC. The significance of clinical significance. Pain. 2008 Jul 31;137(3):467-468. doi: 10.1016/j.pain.2008.03.029. Epub 2008 May 1. No abstract available.Background
Morley S, Williams A, Hussain S. Estimating the clinical effectiveness of cognitive behavioural therapy in the clinic: evaluation of a CBT informed pain management programme. Pain. 2008 Jul 31;137(3):670-680. doi: 10.1016/j.pain.2008.02.025. Epub 2008 Apr 3.Background
Dysvik E, Kvaloy JT, Stokkeland R, Natvig GK. The effectiveness of a multidisciplinary pain management programme managing chronic pain on pain perceptions, health-related quality of life and stages of change--A non-randomized controlled study. Int J Nurs Stud. 2010 Jul;47(7):826-35. doi: 10.1016/j.ijnurstu.2009.12.001. Epub 2009 Dec 29.
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History
Started
Nov 2018
Main results due
Aug 2022
Finished
Aug 2022