Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis

CompletedNot a drug-phase studyMS (type not specified)NCT03856801

What it found

No results found

We found no results in the registry or in papers.

This trial finished 8 years ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Exercise

What it measured

Main measures

  • Maximal Voluntary Isometric Contraction of Knee Extension

    Immediately before the training sessions

  • Maximal Voluntary Isometric Contraction of Knee Extension

    Immediately after the training sessions

  • Rate of Force Development

    Immediately before the training sessions

  • Rate of Force Development

    Immediately after the training sessions

  • Central Activation Ratio

    Immediately before the training sessions

  • Central Activation Ratio

    Immediately after the training sessions

  • Biomechanical study of the walk by video recording

    Immediately before the training sessions

    Walking and mobility
  • Biomechanical study of the walk by video recording

    Immediately after the training sessions

    Walking and mobility
  • Spasticity

    Immediately before the training sessions

    Spasticity
  • Spasticity

    Immediately after the training sessions

    Spasticity

Other measures (8)

  • Rate of Perceived Exertion

    Immediately before the training sessions

  • Rate of Perceived Exertion

    Immediately after the training sessions

  • Walking speed

    Immediately before the training sessions

    Walking and mobility
  • Walking speed

    Immediately after the training sessions

    Walking and mobility
  • Static balance

    Immediately before the training sessions

    Walking and mobility
  • Static balance

    Immediately after the training sessions

    Walking and mobility
  • Muscle oxygenation in soleus

    Immediately before the training sessions

  • Muscle oxygenation in soleus

    Immediately after the training sessions

Who could take part

MS (type not specified) · 18 to 65

Show the full criteria

Inclusion criteria

* mild or moderate disability with clinical mild spastic-ataxic gait disorder. * stable phase of the disease.

Exclusion criteria

* Expanded Disability Status Scale (EDSS) \< 6. * relapsing disease within the preceding 12 months. * corticosteroid treatment within the last months before study inclusion.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

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History

    1. Started

      Jun 2018

    2. Main results due

      Jul 2018

    3. Finished

      Aug 2018

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